2021
DOI: 10.1016/j.jmb.2021.166892
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Regulatory Networks of the T4SS Control: From Host Cell Sensing to the Biogenesis and the Activity during the Infection

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Cited by 7 publications
(3 citation statements)
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“…In comparison to other T4BSS models, high temperatures do not seem to be an inductive signal for dot/icm gene expression. Indeed, within phagocytes, dot/icm and related effectors expression is induced by nutrient deficiency in the Legionella -containing vacuole (LCV), whereas acidic pH and specific amino acid composition (phenylalanin, proline and serine) are signals inducing dot/icm gene expression in the Coxiella -containing vacuole (CCV) (Jaboulay et al, 2021; Al-Khodor et al, 2009; Newton et al, 2020). Concerning P. putida , no gene expression study has been performed so far, but the T4BSS is functional in bacterial killing in environmental conditions (30°C) (Purtschert-Montenegro et al, 2022).…”
Section: Discussionmentioning
confidence: 99%
“…In comparison to other T4BSS models, high temperatures do not seem to be an inductive signal for dot/icm gene expression. Indeed, within phagocytes, dot/icm and related effectors expression is induced by nutrient deficiency in the Legionella -containing vacuole (LCV), whereas acidic pH and specific amino acid composition (phenylalanin, proline and serine) are signals inducing dot/icm gene expression in the Coxiella -containing vacuole (CCV) (Jaboulay et al, 2021; Al-Khodor et al, 2009; Newton et al, 2020). Concerning P. putida , no gene expression study has been performed so far, but the T4BSS is functional in bacterial killing in environmental conditions (30°C) (Purtschert-Montenegro et al, 2022).…”
Section: Discussionmentioning
confidence: 99%
“…4B), suggesting the involvement of additional regulatory routes such as transcription of regulatory genes 62 and post-transcriptional regulation. Reports on the importance of post-transcriptional regulation of the conjugative process have been previously described 55 and were highlighted as a promising regulatory mechanism of conjugation 63 . In line with our observations, previous work has reported on substantial differences between levels of transcripts versus proteins of the T4SS, with higher transcription levels in poor media compared to rich media.…”
Section: Discussionmentioning
confidence: 99%
“…Type IV secretion system (T4SS) genes, which mediate plasmid conjugation transfer, have also been identified in pSHX180-NDM5, indicating that pSHX180-NDM5 might be self-transmissible and mediate the dissemination of antibiotic resistance. In addition to facilitating plasmid conjugation, T4SS is associated with virulence in Gram-negative organisms ( 21 , 22 ). In adherent-invasive E. coli , T4SS acts as a principal Escherichia coli colonization factor to form biofilms on the surface of epithelial cells ( 23 ).…”
Section: Discussionmentioning
confidence: 99%