Regulatory Non-Coding RNAs in Familial Hypercholesterolemia, Theranostic Applications

Abstract

Familial hypercholesterolemia (FH) is a common monogenic disease which is associated with high serum levels of low-density lipoprotein cholesterol (LDL-C) and leads to atherosclerosis and cardiovascular disease (CVD). Early diagnosis and effective treatment strategy can significantly improve prognosis. Recently, non-coding RNAs (ncRNAs) have emerged as novel biomarkers for the diagnosis and innovative targets for therapeutics. Non-coding RNAs have essential roles in the regulation of LDL-C homeostasis, suggesting that manipulation and regulating ncRNAs could be a promising theranostic approach to ameliorate clinical complications of FH, particularly cardiovascular disease. In this review, we briefly discussed the mechanisms and pathophysiology of FH and novel therapeutic strategies for the treatment of FH. Moreover, the theranostic effects of different non-coding RNAs for the treatment and diagnosis of FH were highlighted. Finally, the advantages and disadvantages of ncRNA-based therapies vs. conventional therapies were discussed.

Recent advancement in the detection of potential cancer biomarkers using the nanomaterial integrated electrochemical sensing technique: a detailed review

“…It is regarded as one of the finest indicators for the electrochemical sensing method's early cancer diagnosis. 140 In 2020 Meng et al summarized and reported the enzymatic activities of MNCs and explored their applications in different fields, such as molecular diagnostics and pollution removal. 141 They placed particular emphasis on MNCs manufactured with protein as a protective agent.…”

Emerging Role of MicroRNA-30c in Neurological Disorders

“…In addition to cerebral ischemia reperfusion (I/R) models [43,44], a large body of data from other experimental models including human data indicates the biomarker and protective effects of miR-30c against I/R damage [45][46][47][48][49][50]. Existing evidence suggests that miR-30c attenuates cardiovascular dysfunctions [51][52][53], hyperglycemia [54][55][56], obesity [57], atherosclerosis [58][59][60], dyslipidemia [17], and hepatic lipoprotein production [61,62], which constitute major risk factors in stroke and other neurological disorders. MiR-30c potentiates prosurvival anti-apoptotic pathways [63][64][65].…”