Regulatory perspectives of Herbal Medicinal Products

Ali, Faraat; Khasimbi, Shaik; Sharma, K. R.; Trivedi, Manisha; Ali, Asghar; Ahmad, Javed

doi:10.2174/9789811464485120010012

Bioactive Phytochemicals: Drug Discovery to Product Development 2020

DOI: 10.2174/9789811464485120010012

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Regulatory perspectives of Herbal Medicinal Products

Faraat Ali¹,

Shaik Khasimbi²,

K. R. Sharma³

et al.

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2023

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An evaluation of the quality of Annona muricata leaf products

Jocelin Chan,

Harnett,

Meroni

et al. 2023

Journal of Pharmacy and Pharmacology

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Objectives Annona muricata, also known as graviola, is traditionally used for the treatment of a range of disorders including cancer. Interest in A. muricata use has increased in recent years. This study investigated the quality and safety of a selection of commercially available A. muricata leaf products. Methods Seven commercially available products were purchased via online shopping sites. Each product was assessed for quality indicators including weight variation, quantification of the bioactive constituent annonacin, presence of annonaceous acetogenins and contaminants. The samples were evaluated by thin-layer chromatography, high-performance liquid chromatography, liquid chromatography–mass spectroscopy, low-resolution mass spectrometry and nuclear magnetic resonance spectroscopy. Microbial analysis was carried out in accordance with the British Pharmacopoeia. Heavy metals were analysed by inductive coupled plasma mass spectrometry. Key findings Of the seven products analysed, one product contained less than half of the content stated on the label. The labelled dosage recommendation varied between products. There was a high variation in annonacin concentration (1.05–3.09 mg/g) and the presence of annonaceous acetogenins. One of the products was found to have a total aerobic microbial count above the United States Pharmacopoeia limit. Conclusions The variation in the indicators of quality and safety of commercially available A. muricata leaf products tested have implications for clinicians and people living with cancer who use these herbal products.

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An evaluation of the quality of Annona muricata leaf products

Jocelin Chan,

Harnett,

Meroni

et al. 2023

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

show abstract

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Regulatory perspectives of Herbal Medicinal Products

Cited by 1 publication

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An evaluation of the quality of Annona muricata leaf products

An evaluation of the quality of Annona muricata leaf products

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