Regulatory role of adenosine in antigen-induced histamine release from the lung tissue of actively sensitized guinea pigs

Welton, Ann F.; Simko, B.

doi:10.1016/0006-2952(80)90400-1

Cited by 58 publications

(27 citation statements)

References 33 publications

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“…In contrast to our observations, others have shown that adenosine added after challenge with antigen causes a modest stimulation of the release of histamine from human blood basophils (Church et al, 1982) and from mast cells isolated from human lung fragments (Church et al, 1983) and guinea-pig lung where pretreatment with adenosine enhances antigen-induced release of histamine (Marquardt et al, 1978;Welton & Simko, 1980;Holgate et al, 1980;Sydbom & Fredholm, 1982).…”

Section: ) Does Not Inhibit the Release Of Histamine Or Srs-acontrasting

confidence: 99%

Characterization of the adenosine receptor responsible for the inhibition of histamine and SRS‐A release from human lung fragments

Hillyard

Nials

Skidmore

et al. 1984

British J Pharmacology

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1 The inhibitory effects of a range of natural and synthetic derivatives of adenosine on the antigen-induced release of histamine and slow reacting substance of anaphylaxis (SRS-A) from human lung has been studied. 2 The nucleotides ATP, ADP and AMP appear to act by being converted to adenosine. 3 The rank order of inhibitory potency of the synthetic analogues indicates that these compounds act at an extracellular A2/Ra purinoceptor. 4 The xanthines, 1, 3-diethyl-8-phenylxanthine, 8-phenyltheophylline and theophylline antagonized the inhibitory action of N-ethyl-carboxamideadenosine competitively. Theobromine was inactive. This supports the view that the inhibitory receptor is of the A/R type. 5 Hexobendine and dipyridamole, reported to antagonize the uptake of adenosine, failed to modify the response of human lung fragments to adenosine. 6 The P site agonist 2', 5' dideoxyadenosine inhibited the release of histamine and SRS-A. This effect was not prevented by the inhibitors of uptake, hexobendine and dipyridamole, nor was it antagonized by 8-phenyltheophylline.

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Section: ) Does Not Inhibit the Release Of Histamine Or Srs-acontrasting

confidence: 99%

Characterization of the adenosine receptor responsible for the inhibition of histamine and SRS‐A release from human lung fragments

Hillyard

Nials

Skidmore

et al. 1984

British J Pharmacology

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“…In vitro, adenosine has been shown to potentiate IgE-dependent mediator release, both from rat isolated mast cells (Holgate et al, 1980) and guinea pig lung fragments (Welton & Simko, 1980 Farmer & Farrar, 1976). questioned (Stoclet, 1980;Fredholm, 1980a). Conchanism of adenosine-induced broncho-centrations of theophylline at the top of the theran in asthma is at present obscure.…”

Section: Discussionmentioning

confidence: 99%

Inhaled adenosine and guanosine on airway resistance in normal and asthmatic subjects.

Cushley¹,

Tattersfield²,

Holgate³

1983

Brit J Clinical Pharma

388

152

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1 The airway response to the inhaled nucleosides, adenosine (6.7 x 10-4-6.7 mg/ml) and guanosine (7.3 x 10-4-1.4 mg/ml) was studied in normal and asthmatic subjects. Airway response, measured in the body plethysmograph, was expressed as percentage change in specific airway conductance (sGaw) from baseline.2 Inhaled adenosine caused no change in sGaw in normal subjects but produced a dose-dependent reduction in sGaw in both allergic and non-allergic asthmatic subjects (76 and 62% reduction respectively at 6.7 mg/ml).3 Kinetics of adenosine induced bronchoconstriction were studied in 12 asthmatic subjects who inhaled a single concentration of adenosine. Bronchoconstriction was maximal within 5 min (42% reduction in sGaw) with partial recovery by 30 min. 4 The related nucleoside guanosine caused no change in sGaw in normal or asthmatic subjects. 5 Adenosine, but not guanosine, is a potent bronchoconstrictor in asthma suggesting that it may have a specific pharmacological effect.

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“…In rat mast cells (Marquardt, Parker & Sullivan, 1978;Holgate et al, 1980a) and guinea-pig lung tissue (Welton & Simko, 1980) adenosine and analogues which interact with cell surface Al-and A2-receptors but not those which interact with intracellular P-sites, potentiate immunological histamine release. Conversely, preincubation of human basophil leucocytes with adenosine inhibits IgEdependent mediator release (Marone, Findlay & Lichtenstein, 1979).…”

Section: Introductionmentioning

confidence: 99%

Adenosine inhibits and potentiates IgE‐dependent histamine release from human basophils by an A₂‐receptor mediated mechanism

Church

Holgate

Hughes

1983

British J Pharmacology

103

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1Adenosine added to human basophils before anti-IgE challenge inhibited histamine release, whereas addition after challenge potentiated release. Peak responses for the two effects occurred 15 min before and after challenge respectively. 2 The effects of adenosine on histamine secretion were dose-related over concentration ranges of 1-100 tAM for inhibition and 0.01-1 gM for potentiation. 3 The capacity of adenosine to inhibit and potentiate histamine secretion was inversely related to the strength of immunological challenge.4 The ability of theophylline (50 JM) to inhibit and dipyridamole (1 jAM) to enhance slightly adenosine-induced responses, and the differing pharmacological effect of 2',5'-dideoxyadenosine suggested that adenosine's effects on basophil histamine secretion were mediated by stimulation of cell surface adenosine receptors.

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Regulatory role of adenosine in antigen-induced histamine release from the lung tissue of actively sensitized guinea pigs

Cited by 58 publications

References 33 publications

Characterization of the adenosine receptor responsible for the inhibition of histamine and SRS‐A release from human lung fragments

Characterization of the adenosine receptor responsible for the inhibition of histamine and SRS‐A release from human lung fragments

Inhaled adenosine and guanosine on airway resistance in normal and asthmatic subjects.

Adenosine inhibits and potentiates IgE‐dependent histamine release from human basophils by an A₂‐receptor mediated mechanism

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Regulatory role of adenosine in antigen-induced histamine release from the lung tissue of actively sensitized guinea pigs

Cited by 58 publications

References 33 publications

Characterization of the adenosine receptor responsible for the inhibition of histamine and SRS‐A release from human lung fragments

Characterization of the adenosine receptor responsible for the inhibition of histamine and SRS‐A release from human lung fragments

Inhaled adenosine and guanosine on airway resistance in normal and asthmatic subjects.

Adenosine inhibits and potentiates IgE‐dependent histamine release from human basophils by an A2‐receptor mediated mechanism

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Adenosine inhibits and potentiates IgE‐dependent histamine release from human basophils by an A₂‐receptor mediated mechanism