Regulatory Role of Supramolecular Alcohol Dehydrogenase and Lactate Dehydrogenase Complex in Cell Mitochondria

Abstract

The existence of a supramolecular alcohol dehydrogenase-lactate dehydrogenase complex was demonstrated. Enzyme activities were evaluated in a preparation of mitochondrial membranes from mouse liver. The role of the enzyme complex (alcohol dehydrogenase-lactate dehydrogenase) in the regulation of pyruvate and acetaldehyde metabolism in the cell was studied.