Regulatory role of T helper 9/interleukin-9: Transplantation view

Roostaee, Azadeh; Yaghobi, Ramin; Afshari, Afsoon; Jafarinia, Mojtaba

doi:10.1016/j.heliyon.2024.e26359

Cited by 2 publications

(1 citation statement)

References 112 publications

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“…Tumor-infiltrating Th9 lymphocytes release the characteristic cytokine IL-9, which has been implicated in various immune and inflammatory diseases, including parasitic infections, allergies, and lymphoma ( 122 ). However, the precise and consistent role of IL-9 in tumor immunity remains enigmatic and subject to controversy ( Figure 2 ).…”

Section: Direct Tumor-promoting Effects Of Immune Cells and Their Cou...mentioning

confidence: 99%

Immunocytes interact directly with cancer cells in the tumor microenvironment: one coin with two sides and future perspectives

Ye,

Cheng,

Huang

et al. 2024

Front. Immunol.

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The tumor microenvironment is closely linked to the initiation, promotion, and progression of solid tumors. Among its constitutions, immunologic cells emerge as critical players, facilitating immune evasion and tumor progression. Apart from their indirect impact on anti-tumor immunity, immunocytes directly influence neoplastic cells, either bolstering or impeding tumor advancement. However, current therapeutic modalities aimed at alleviating immunosuppression from regulatory cells on effector immune cell populations may not consistently yield satisfactory results in various solid tumors, such as breast carcinoma, colorectal cancer, etc. Therefore, this review outlines and summarizes the direct, dualistic effects of immunocytes such as T cells, innate lymphoid cells, B cells, eosinophils, and tumor-associated macrophages on tumor cells within the tumor microenvironment. The review also delves into the underlying mechanisms involved and presents the outcomes of clinical trials based on these direct effects, aiming to propose innovative and efficacious therapeutic strategies for addressing solid tumors.

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Section: Direct Tumor-promoting Effects Of Immune Cells and Their Cou...mentioning

confidence: 99%

Immunocytes interact directly with cancer cells in the tumor microenvironment: one coin with two sides and future perspectives

Ye,

Cheng,

Huang

et al. 2024

Front. Immunol.

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Th17 cell function in cancers: immunosuppressive agents or anti-tumor allies?

Anvar,

Rashidan,

Arsam

et al. 2024

Cancer Cell Int

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T helper (Th) 17 cells, a distinct subset of Th lymphocytes, are known for their prominent interleukin (IL)-17 production and other pro-inflammatory cytokines. These cells exhibit remarkable plasticity, allowing them to exhibit different phenotypes in the cancer microenvironment. This adaptability enables Th17 cells to promote tumor progression by immunosuppressive activities and angiogenesis, but also mediate anti-tumor immune responses through employing immune cells in tumor setting or even by directly converting toward Th1 phenotype and producing interferon-gamma (IFN-γ). This dual role of Th17 cells in cancer makes it a double-edged sword in encountering cancer. In this review, we aim to elucidate the complexities of Th17 cell function in cancer by summarizing recent studies and, ultimately, to design novel therapeutic strategies, especially targeting Th17 cells in the tumor milieu, which could pave the way for more effective cancer treatments.

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Regulatory role of T helper 9/interleukin-9: Transplantation view

Cited by 2 publications

References 112 publications

Immunocytes interact directly with cancer cells in the tumor microenvironment: one coin with two sides and future perspectives

Immunocytes interact directly with cancer cells in the tumor microenvironment: one coin with two sides and future perspectives

Th17 cell function in cancers: immunosuppressive agents or anti-tumor allies?

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