Regulatory roles of CARD9-BCL10-Rac1 (CBR) signalome in islet β-cell function in health and metabolic stress: Is there room for MALT1?

Kowluru, Anjaneyulu

doi:10.1016/j.bcp.2023.115889

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2024

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Cited by 2 publications

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“… 34 Both factors are crucial for maintaining normal glucose levels, and their dysregulation can contribute to diabetes. 35 , 36 HSI can also reflect the level of insulin-like growth factor 1 (IGF-1) in the body, and the IGF-1 signaling pathway plays a vital role in preserving the b-cell differentiation phenotype. Failure in b-cell function can lead to T2DM development.…”

Section: Discussionmentioning

confidence: 99%

Association Between the Hepatic Steatosis Index and Risk of Incident Type 2 Diabetes Mellitus in the Normoglycemic Population:A Longitudinal Prospective Study in Japan

Si,

Xiao,

Zheng

et al. 2024

DMSO

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Section: Discussionmentioning

confidence: 99%

Association Between the Hepatic Steatosis Index and Risk of Incident Type 2 Diabetes Mellitus in the Normoglycemic Population:A Longitudinal Prospective Study in Japan

Si,

Xiao,

Zheng

et al. 2024

DMSO

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Effects of NaV1.5 and Rac1 on the Epithelial-Mesenchymal Transition in Breast Cancer

Zha,

Ge,

et al. 2024

Cell Biochem Biophys

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Breast cancer is a disease that seriously endangers the health of women. However, it is difficult to treat due to the emergence of metastasis and drug resistance. Exploring the metastasis mechanism of breast cancer is helpful to aim for the appropriate target. The epithelial-mesenchymal transition (EMT) is an important mechanism of breast cancer metastasis. Sodium channel 1.5(NaV1.5) and the GTPase Rac1 are factors related to the degree of malignancy of breast tumors. The expression of NaV1.5 and the activation of Rac1 are both involved in EMT. In addition, NaV1.5 can change the plasma membrane potential (Vm) by promoting the inflow of Na+ to depolarize the cell membrane, induce the activation of Rac1 and produce a cascade of reactions that lead to EMT in breast cancer cells; this sequence of events further induces the movement, migration and invasion of tumor cells and affects the prognosis of breast cancer patients. In this paper, the roles of NaV1.5 and Rac1 in EMT-mediated breast cancer progression were reviewed.

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Regulatory roles of CARD9-BCL10-Rac1 (CBR) signalome in islet β-cell function in health and metabolic stress: Is there room for MALT1?

Cited by 2 publications

References 77 publications

Association Between the Hepatic Steatosis Index and Risk of Incident Type 2 Diabetes Mellitus in the Normoglycemic Population:A Longitudinal Prospective Study in Japan

Association Between the Hepatic Steatosis Index and Risk of Incident Type 2 Diabetes Mellitus in the Normoglycemic Population:A Longitudinal Prospective Study in Japan

Effects of NaV1.5 and Rac1 on the Epithelial-Mesenchymal Transition in Breast Cancer

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