Regulatory roles of three miRNAs on allergen mRNA expression in <i>Tyrophagus putrescentiae</i>

Zhou, Ying; Li, Qingqing; Pan, Ruilin; Wang, Qiong; Zhu, Xuming; Yuan, Cunyin; Cai, Fangfang; Gao, Yuwei; Cui, Yubao

doi:10.1111/all.15111

Cited by 50 publications

(4 citation statements)

References 45 publications

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“…224 The immune characteristics of VZV-infected arteries and the specific immune mechanisms involved in VZV-associated neuroinflammation are not fully elucidated. 225,226 While antiviral drugs and corticosteroids are used to treat VZV-associated neuroinflammation, the effectiveness of these treatments is limited, and there is a need for more targeted and effective therapies. 224 While it is known that VZV can have serious clinical consequences in immunocompromised subjects and adults, the specific immune mechanisms that contribute to the pathogenesis of VZV-associated neuroinflammation in these populations are not well understood.…”

Section: Emerging Research Directions and Gaps In Our Understandingmentioning

confidence: 99%

“…PHN is the most common and consequential consequence of VZV reactivation, although its aetiology is unclear and its therapy is often ineffectual 224 . The immune characteristics of VZV‐infected arteries and the specific immune mechanisms involved in VZV‐associated neuroinflammation are not fully elucidated 225,226 . While antiviral drugs and corticosteroids are used to treat VZV‐associated neuroinflammation, the effectiveness of these treatments is limited, and there is a need for more targeted and effective therapies 224 .…”

Section: Therapeutic Approaches and Future Directionsmentioning

confidence: 99%

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Varicella‐zoster virus‐related neurological complications: From infection to immunomodulatory therapies

Hakami,

Khan,

Abdulaziz

et al. 2024

Reviews in Medical Virology

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The Varicella‐zoster virus (VZV), classified as a neurotropic member of the Herpesviridae family, exhibits a characteristic pathogenicity, predominantly inducing varicella, commonly known as chickenpox, during the initial infectious phase, and triggering the reactivation of herpes zoster, more commonly recognized as shingles, following its emergence from a latent state. The pathogenesis of VZV‐associated neuroinflammation involves a complex interplay between viral replication within sensory ganglia and immune‐mediated responses that contribute to tissue damage and dysfunction. Upon primary infection, VZV gains access to sensory ganglia, establishing latent infection within neurons. During reactivation, the virus can spread along sensory nerves, triggering a cascade of inflammatory mediators, chemokines, and immune cell infiltration in the affected neural tissues. The role of both adaptive and innate immune reactions, including the contributions of T and B cells, macrophages, and dendritic cells, in orchestrating the immune‐mediated damage in the central nervous system is elucidated. Furthermore, the aberrant activation of the natural defence mechanism, characterised by the dysregulated production of immunomodulatory proteins and chemokines, has been implicated in the pathogenesis of VZV‐induced neurological disorders, such as encephalitis, myelitis, and vasculopathy. The intricate balance between protective and detrimental immune responses in the context of VZV infection emphasises the necessity for an exhaustive comprehension of the immunopathogenic mechanisms propelling neuroinflammatory processes. Despite the availability of vaccines and antiviral therapies, VZV‐related neurological complications remain a significant concern, particularly in immunocompromised individuals and the elderly. Elucidating these mechanisms might facilitate the emergence of innovative immunomodulatory strategies and targeted therapies aimed at mitigating VZV‐induced neuroinflammatory damage and improving clinical outcomes. This comprehensive understanding enhances our grasp of viral pathogenesis and holds promise for pioneering therapeutic strategies designed to mitigate the neurological ramifications of VZV infections.

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Section: Emerging Research Directions and Gaps In Our Understandingmentioning

confidence: 99%

Section: Therapeutic Approaches and Future Directionsmentioning

confidence: 99%

Varicella‐zoster virus‐related neurological complications: From infection to immunomodulatory therapies

Hakami,

Khan,

Abdulaziz

et al. 2024

Reviews in Medical Virology

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“…To the Editor, Tyrophagus putrescentiae is a medically important mite species causing allergies worldwide. 1,2 More than 20 IgE-reactive components are detectable in T. putrescentiae extracts. 3 The World Health Organization/International Union of Immunological Societies (WHO/IUIS) Allergen Nomenclature Sub-Committee lists 12 allergens from T. putrescentiae: Tyr p 1-3, 7, 8, 10, 13, 20, 28, and 34-36.…”

Section: Chromosome-level Genomic Assembly and Allergome Inference Re...mentioning

confidence: 99%

Chromosome‐level genomic assembly and allergome inference reveal novel allergens in Tyrophagus putrescentiae

Zhou

Klimov

et al. 2023

Allergy

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“…They found that miRNAs could bind to target allergen‐encoding mRNAs, thereby highlighting the role of miRNAs in regulating the expression of allergen‐encoding mRNAs in mites. These findings will help us develop novel treatment strategies for allergic diseases caused by dust mites 17 …”

mentioning

confidence: 95%

The past, present, and future of allergic diseases in China

Zhang

Akdiş

2022

Allergy

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The past, present, and future of allergic diseases in ChinaAllergic diseases have become a global health problem and pose a significant burden on healthcare resources due to their increasing prevalence, severity, chronic nature, and associated management cost. If the current increasing trend continues, it is expected that allergic diseases will reach 4 billion cases worldwide by the 2050s. 1,2 Currently, approximately 30%-40% of the global population suffers from some form of allergies, and an increasing trend in the prevalence of various allergic diseases has been reported in China in recent years. 3 A national cross-sectional China Pulmonary Health study reported that the overall prevalence of asthma was 4.2%, and a 6-year period survey based on 18 major cities found that the prevalence of self-reported allergic rhinitis (AR) was 17.6%. 4 Furthermore, another multi-center study demonstrated that the overall prevalence of selfreported AR and physician-diagnosed AR was 32.4% and 18.5%, respectively, in the northern grassland region of China. 5 Zheng et al.

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Regulatory roles of three miRNAs on allergen mRNA expression in Tyrophagus putrescentiae

Cited by 50 publications

References 45 publications

Varicella‐zoster virus‐related neurological complications: From infection to immunomodulatory therapies

Varicella‐zoster virus‐related neurological complications: From infection to immunomodulatory therapies

Chromosome‐level genomic assembly and allergome inference reveal novel allergens in Tyrophagus putrescentiae

The past, present, and future of allergic diseases in China

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