2023
DOI: 10.1101/2023.02.13.528205
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Regulatory T Cell-like Response to SARS-CoV-2 in Jamaican Fruit Bats (Artibeus jamaicensis) Transduced with Human ACE2

Abstract: Insectivorous Old World horseshoe bats (Rhinolophus spp.) are the likely source of the ancestral SARS-CoV-2 prior to its spillover into humans and causing the COVID-19 pandemic. Natural coronavirus infections of bats appear to be principally confined to the intestines, suggesting fecal-oral transmission; however, little is known about the biology of SARS-related coronaviruses in bats. Previous experimental challenges of Egyptian fruit bats (Rousettus aegyptiacus) resulted in limited infection restricted to the… Show more

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Cited by 8 publications
(5 citation statements)
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“…Similarly, we did not observe signi cant upregulation of host anti-viral genes after in vivo infection. Interestingly, even the addition of human ACE2 into the bats through intranasal adenovirus vector infection by Burke et al was able to only nominally overcome this restriction: though this led to an increased number of ACE2 expressing cells in the lungs, viral RNA could only be found in one out of four bats on days 4 and 7 [23]. This suggests that the intrinsic ability of Jamaican fruit bats to restrict replication after entry may in principle be overcome through a dose effect, though not e ciently.…”
Section: Discussionmentioning
confidence: 99%
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“…Similarly, we did not observe signi cant upregulation of host anti-viral genes after in vivo infection. Interestingly, even the addition of human ACE2 into the bats through intranasal adenovirus vector infection by Burke et al was able to only nominally overcome this restriction: though this led to an increased number of ACE2 expressing cells in the lungs, viral RNA could only be found in one out of four bats on days 4 and 7 [23]. This suggests that the intrinsic ability of Jamaican fruit bats to restrict replication after entry may in principle be overcome through a dose effect, though not e ciently.…”
Section: Discussionmentioning
confidence: 99%
“…This contrasts with the ndings by Burke et al, where the authors report that challenge of Jamaican fruit bats with SARS-CoV-2 Lineage A allowed detection of antigen for 2 days in the intestinal, but not the respiratory, tract. They also observed no seroconversion and no transmission [23]. Sarbecoviruses are suggested to have an intestinal tract tropism in bat hosts, with virus RNA found in fecal samples and a suggested fecal-oral transmission route [62-64].…”
Section: Discussionmentioning
confidence: 99%
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“…Jamaican fruit bats (Artibeus jamaicensis) are native to the Caribbean and Central and South America and represent an underdeveloped animal model for immunology research. Jamaican fruit bats are a natural reservoir of H18N11 influenza A virus, and the species is used to study other viral infections as a surrogate host, including SARS-CoV-2, MERS-CoV, Zika virus, rabies virus and Tacaribe virus [11][12][13][14][15]. The lack of immunological reagents for bats constrains the use of high throughput technologies, such as flow cytometry and cell sorting, and quantitative data and anatomical determination from fluorescence microscopy.…”
Section: Introductionmentioning
confidence: 99%
“…Activation of interleukin 1b (IL-1b) processing via caspase is suppressed in bats (Shaw et al, 2017;Goh et al, 2020) and unlike the intense and chronic inflammatory response of other mammals, bats can partially suppress the immune response against viruses (David et al, 2022). Other cytokines such as IL-10 and transforming growth factor b (TGFb), with a potential anti-inflammatory function, appear to be upregulated in bats during in vivo infection with viruses (Burke et al, 2023). Compared to mouse (Mus musculus) macrophages, the greater mouse-eared bat (Myotis myotis) macrophages possessed a robust anti-inflammatory response that is most likely related to viral tolerance in bats (Kacprzyk et al, 2017).…”
mentioning
confidence: 99%