Regulatory T Cell Plasticity and Stability and Autoimmune Diseases

Qiu, Runze; Zhou, Liyu; Ma, Yuanjing; Zhou, Lingling; Tao, Liang; Shi, Le; Long, Jun; Yuan, Dongping

doi:10.1007/s12016-018-8721-0

Cited by 104 publications

(66 citation statements)

References 262 publications

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“…al reported that CVID patients with bronchiectasis had more autoimmune complications such as autoimmune hematologic diseases, hepatomegaly, splenomegaly and lymphadenopathy than CVID patients without bronchiectasis (28). Regulatory T cells (T-regs) play an important role in the preservation of immune homeostasis (29). Romberg et al reported that a decreased number of T-regs, reduced T-reg function and an increased number of follicular T cells in the germinal center of lymph nodes might correlate with fewer isotype switched memory B cells (30).…”

Section: Discussionmentioning

confidence: 99%

Risk Factors of Bronchiectasis in Adult Patients with Common Variable Immunodeficiency

Aytekin¹,

Çölkesen²,

Yıldız³

et al. 2019

Asthma Allergy Immunol

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Objective: Common Variable Immunodeficiency (CVID) is a heterogeneous immune disorder characterized by frequent and recurrent upper and lower respiratory tract infections. Although immunoglobulin (Ig) replacement therapy (IgRT) reduces the frequency of infections, complications due to infections of the respiratory tract, particularly bronchiectasis, is still challenging and occur in approximately 20% of patients. Therefore, we aimed to identify independent predictors of bronchiectasis in adult patients with CVID. Materials and Methods:We retrospectively analyzed the hospital records of 45 CVID patients (26 male, 19 female). Additionally, we classified the patients according to the presence of bronchiectasis. Bronciectasis was confirmed by high resolution computed tomography of thorax.Results: Forty-five patients with CVID (F:19 [42.2%], M: 26 [57.8%]) were included in the study (age: 36.52 ± 12.86). Bronchiectasis was observed in 60% of the study group. Univariate regression analysis revealed that IgG levels (OR: 4.889, 95% CI, 0.485-0.959, p: 0.012) and IgA levels (OR: 2.559, 95% CI, 0.097-1.235, p: 0.030) at the time of diagnosis and the percentage of switched memory B cells (OR: 0.848, 95% CI, 0.730-0.984, p: 0.030) were significantly associated with bronchiectasis. Multivariate regression analysis showed that a lower percentage of switched memory B cells (OR: 0.853, 95% CI, 0.733-0.991, p: 0.038) and a low platelet count (OR: 1.000, 95% CI, 1.000-1000, p: 0.026) were also independent predictors of bronchiectasis. Conclusion:Clinicians should be alert for CVID patients with reduced switched memory B cells and low platelet counts in order to detect and treat complications associated with bronchiectasis at an early stage.

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Section: Discussionmentioning

confidence: 99%

Risk Factors of Bronchiectasis in Adult Patients with Common Variable Immunodeficiency

Aytekin¹,

Çölkesen²,

Yıldız³

et al. 2019

Asthma Allergy Immunol

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“…Immunotherapy with transplanted Treg cells has been used in autoimmune diseases and other immune-associated diseases, including type-1 diabetes mellitus, systemic lupus erythematosus (SLE) and graft vs. host disease (GVHD) (7–13). Culturing sufficient numbers of Treg cells in vitro is the foundation of Treg-based immunotherapy, and maintaining the stable inhibitory function of Treg cells in vivo is pivotal for successful treatment (8,9). However, the stability and inhibitory function of Treg cells in the internal inflammatory environment requires further systematic investigation.…”

Section: Introductionmentioning

confidence: 99%

“…The internal environment of patients with autoimmune diseases is complex and there may be inflammation or elevated levels of inflammatory cytokines, including tumour necrosis factor-α, interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-23 (IL-23) and interferon-γ (IFN-γ) expressed in human atherosclerotic plaques (14,15); interleukin-17 (IL-17), IFN-γ, IL-6 and IL-23 expressed in type 1 diabetes mellitus (16); IL-1β and IL-17 expressed in SLE (17); and IL-6 expressed in GVHD (9,18). IL-6 is the critical cytokine that mediates inflammation (18,19).…”

Section: Introductionmentioning

confidence: 99%

Stability and inhibitory function of Treg cells under inflammatory conditions in�vitro

et al. 2019

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Immunotherapy with transplanted T-regulatory (Treg) cells is currently in use. However, patients have complex internal environments with confounding factors, including the presence of inflammatory cytokines. The present study aimed to detect Treg cell function under simulated inflammatory conditions to provide a foundation for Treg cell-based immunotherapy. CD4+CD25high Treg cells were sorted from peripheral blood mononuclear cells and cultured for 14 days in the presence of recombinant human interleukin-2 (rhIL-2) and anti-CD3/CD28 beads, with or without 25 ng/ml rhIL-6. Next, the absolute count of Treg cells was determined, the stability and activity were detected by measuring the expression levels of forkhead box (Fox)P3 and CD39, and the suppressive function of Treg cells was investigated by assessing the suppression of T-effector cell proliferation by Treg cells after co-culture for 5 days. The number of Treg cells cultured in the presence of 25 ng/ml rhIL-6 for 14 days was reduced by 49.7% when compared with that of cells cultured without rhIL-6. Of the Treg cells continually cultured for 14 days without or with 25 ng/ml rhIL-6, 56.15 and 24.7% expressed FoxP3, respectively. There was no difference in the activity of the FoxP3+ Treg cells after culture for 14 days without or with 25 ng/ml rhIL-6. The suppressive function of Treg cells tended to deteriorate in the presence of rhIL-6. In conclusion, IL-6 inhibited the proliferation and stability of Treg cells, suggesting that administration of increased numbers of Treg cells may be required during Treg cell-based immunotherapy.

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“…It has been shown that Saccharomyces [82] and Bacteroides ovatus [83] induce IgA production (an antibody necessary for neutralizing invasive pathogens in the gut) while Lactobacillus reuteri is required for inducing CD4 + CD8αα + double-positive intra-epithelial lymphocytes in germ-free mice [84]. It is also widely accepted that the genus Clostridium induces the accumulation of regulatory T cells [85], which are required for sustaining immune tolerance to allergens [86]. Moreover, Clostridium clusters IV, XIVa, and XVIII induce CD4 + Foxp3 + T reg cells using the short-chain fatty acids they produce [87][88][89].…”

Section: Role Of the Gut Microbiota In Immunity And Homeostasismentioning

confidence: 99%

Health Impact and Therapeutic Manipulation of the Gut Microbiome

et al. 2020

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Recent advances in microbiome studies have revealed much information about how the gut virome, mycobiome, and gut bacteria influence health and disease. Over the years, many studies have reported associations between the gut microflora under different pathological conditions. However, information about the role of gut metabolites and the mechanisms by which the gut microbiota affect health and disease does not provide enough evidence. Recent advances in next-generation sequencing and metabolomics coupled with large, randomized clinical trials are helping scientists to understand whether gut dysbiosis precedes pathology or gut dysbiosis is secondary to pathology. In this review, we discuss our current knowledge on the impact of gut bacteria, virome, and mycobiome interactions with the host and how they could be manipulated to promote health.

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Regulatory T Cell Plasticity and Stability and Autoimmune Diseases

Cited by 104 publications

References 262 publications

Risk Factors of Bronchiectasis in Adult Patients with Common Variable Immunodeficiency

Risk Factors of Bronchiectasis in Adult Patients with Common Variable Immunodeficiency

Stability and inhibitory function of Treg cells under inflammatory conditions in�vitro

Health Impact and Therapeutic Manipulation of the Gut Microbiome

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