Regulatory T-cell populations in children are affected by age and food allergy diagnosis

Prince, Benjamin; Devonshire, Ashley; Erickson, Kristin A.; Bergerson, Jenna; Fuleihan, Dalia; Szychlinski, Christine; Schleimer, Robert P.; Bryce, Paul J.; Singh, Anne Marie

doi:10.1016/j.jaci.2017.04.039

Cited by 15 publications

(12 citation statements)

References 13 publications

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“…It has been hypothesized that memory Treg cells are important to reduce proinflammatory immune responses in atopic disease by anti‐inflammatory cytokine production such as IL‐10 and TGF‐β . Therefore, higher memory Treg cell numbers in our population may indicate that children with allergic sensitization and atopic dermatitis experience a chronic inflammatory immune response that needs to be suppressed . Numbers of Treg cells were highest in food‐allergic sensitization.…”

Section: Discussionmentioning

confidence: 91%

“…12,36,37 Therefore, higher memory Treg cell numbers in our population may indicate that children with allergic sensitization and atopic dermatitis experience a chronic inflammatory immune response that needs to be suppressed. 33,38,39 tion of non-self-antigens. 10,12 We speculate that chronic inflammation as seen in atopic diseases contributes to the production of TGF-β and thereby the increase in peripheral Treg cell numbers.…”

Section: Previous Literature and Interpretationmentioning

confidence: 99%

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Associations of Th2, Th17, Treg cells, and IgA⁺ memory B cells with atopic disease in children: The Generation R Study

Looman

Meel

Großerichter-Wagener

et al. 2019

Allergy

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Background: New insights into immune cells could contribute to treatment and monitoring of atopic disease. Because nongenetic factors shape the human immune system, we here studied these immune cells in a large cohort with atopic children with adjustment for prenatal and postnatal confounders. Methods: Information on atopic dermatitis, inhalant-and food-allergic sensitization, asthma lung function scores was obtained from 855 10-year-old children within the Generation R cohort. 11-color flow cytometry was performed to determine CD27 + and CD27 − IgG + , IgE + and IgA + memory B cells, Th1, Th2, Th17, and Treg-memory cells from venous blood. Associations between any atopic disease, the individual atopic diseases, and immune cell numbers were determined. Results: Children with any atopic disease had higher Th2, Treg, Treg-memory, and CD27 + IgA + memory B-cell numbers compared to children without atopic disease. When studying the individual diseases compared to children without the individual diseases, children with atopic dermatitis, inhalant-, and food-allergic sensitization had higher memory Treg cell numbers 12.3% (95% CI 4.2; 21.0), (11.1% (95% CI 3.0; 19.8), (23.7% (95% CI 7.9; 41.8), respectively. Children with food-allergic sensitization had higher total B and CD27 + IgA + memory B-cell numbers (15.2% [95% CI 3.2; 28.7], 22.5% [95% CI 3.9; 44.3], respectively). No associations were observed between asthma and B-or T-cell numbers. | 179 LOOMAN et AL.

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Section: Discussionmentioning

confidence: 91%

Section: Previous Literature and Interpretationmentioning

confidence: 99%

Associations of Th2, Th17, Treg cells, and IgA⁺ memory B cells with atopic disease in children: The Generation R Study

Looman

Meel

Großerichter-Wagener

et al. 2019

Allergy

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“…38 Atopic children with food allergy have lower percentages of CD25 1 CD127 lo FoxP3 1 Treg cells compared with healthy control subjects of similar age. 39 In addition, age-related increases in Treg cell expression of CCR6 were observed in healthy control subjects but not children with food allergy, which might suggest a delay in Treg cell migration to peripheral sites of inflammation, a likely handicap in the maintenance of immune tolerance.…”

Section: Role Of Treg and Regulatory B Cellsmentioning

confidence: 95%

Mechanisms of food allergy

Sampson

O’Mahony

Burks

et al. 2018

Journal of Allergy and Clinical Immunology

222

116

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Although oral tolerance is the normal physiologic response to ingested antigens, a breakdown in this process appears to have occurred in the past 2 decades, leading to an increasing prevalence of sensitization to food allergens. Over the past decade, basic research has intensified in an attempt to better understand the mechanisms leading to sensitization and disease versus desensitization and short- and long-term tolerance. In this review we assess various factors that can influence tissue and immune responses to food antigens, the current understanding of immune tolerance development, the role of the gastrointestinal microbiota, and current knowledge regarding immunologic mechanisms involved in desensitization and sustained unresponsiveness, although perhaps the latter is more appropriately termed remission.

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“…The percentage of Tregs in allergic patients (2.3%) was significantly lower in AD patients in comparison to healthy controls (4.6%, p = 0.003), even in the asymptomatic AD or food allergy subjects (21). Atopic food-allergic children also had decreased percentages of Treg cells compared with healthy age-matched healthy controls (22). In a recent mouse model study, allergen-specific immunotherapy revealed local suppression of Th2 and infiltration of Treg cells into the skin, and induced local and systemic Treg cells and regulatory NK cells (23).…”

Section: Discussionmentioning

confidence: 88%

Risk factors of zinc deficiency in children with atopic dermatitis

Ehlayel

Bener

2020

Eur Ann Allergy Clin Immunol

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Background and objectives. Zinc deficiency increases risk of infections, allergies and autoimmunity. We wished to determine risk factors in severe atopic dermatitis (AD) and identify of hypozincemia rate. Materials and methods. Retrospective study done on AD children (≤ 14 years) with serum zinc test. Data included demographic and laboratory tests (serum zinc level, IgE, food-specific IgE), and skin tests. Results. 168 AD children, aged 38.9 months with concomitant allergies in 47 (28%), family history of allergies in 131 (80%), and parental consanguinity in 134 (79.9%). AD was mild in 12 (7.2%, SCORAD 15.8) children, moderate in 41 (24.5%, SCORAD 30.4), and severe in 115 (68.3%, SCORAD 69.4). Hypozincemia was observed in 42 (25%, zinc 8.6 ± 1.1 µmoI/L) children and associated only with severe AD (p = 0.0418) and elevated IgE (p = 0.001). Conclusions. Hypozincemia is rather prevalent in AD, and severe AD and high IgE increase its risk. An adjunct oral zinc may help reducing severe poorly responsive AD. is associated with uncommon but significant complications such as infections (4), poor weight gain, marked malnutrition, or trace elements deficiency (5). Published literature on zinc deficiency and its association with AD is increasing. The significance of hypozincemia in AD seems to be poorly understood. There are no studies on how common zinc deficiency is in moderate-to-severe AD among children and on the risk factors. The aims of this study were to determine how common zinc deficiency is among children with AD, and to determine any risk factors for zinc deficiency in these children. Materials and methods In this retrospective study, we reviewed records of all children, 14 years or less, seen at our Pediatric Allergy-Immunology Clinics at Hamad General Hospital with severe AD and serum zinc level tested. Serum zinc level was considered low in AD chil

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Regulatory T-cell populations in children are affected by age and food allergy diagnosis

Cited by 15 publications

References 13 publications

Associations of Th2, Th17, Treg cells, and IgA⁺ memory B cells with atopic disease in children: The Generation R Study

Associations of Th2, Th17, Treg cells, and IgA⁺ memory B cells with atopic disease in children: The Generation R Study

Mechanisms of food allergy

Risk factors of zinc deficiency in children with atopic dermatitis

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Regulatory T-cell populations in children are affected by age and food allergy diagnosis

Cited by 15 publications

References 13 publications

Associations of Th2, Th17, Treg cells, and IgA+ memory B cells with atopic disease in children: The Generation R Study

Associations of Th2, Th17, Treg cells, and IgA+ memory B cells with atopic disease in children: The Generation R Study

Mechanisms of food allergy

Risk factors of zinc deficiency in children with atopic dermatitis

Contact Info

Product

Resources

About

Associations of Th2, Th17, Treg cells, and IgA⁺ memory B cells with atopic disease in children: The Generation R Study

Associations of Th2, Th17, Treg cells, and IgA⁺ memory B cells with atopic disease in children: The Generation R Study