2020
DOI: 10.3389/fimmu.2020.00509
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Regulatory T Cells Beyond Autoimmunity: From Pregnancy to Cancer and Cardiovascular Disease

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Cited by 10 publications
(4 citation statements)
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References 76 publications
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“…In addition, CD24 hi CD38 hi B cells, immature transitional B cells that, in normal individuals exert suppressive effects by IL-10 production but are quantitatively altered and/or functionally impaired in individuals with various autoimmune diseases, resulted in lower levels in young women compared to men [ 35 ]. Furthermore, a positive correlation between DHT levels at birth and higher CD5 + B cells is determined in men in comparison to women [ 82 ]( Table 1 ).…”
Section: Adaptive Immune Systemmentioning
confidence: 99%
“…In addition, CD24 hi CD38 hi B cells, immature transitional B cells that, in normal individuals exert suppressive effects by IL-10 production but are quantitatively altered and/or functionally impaired in individuals with various autoimmune diseases, resulted in lower levels in young women compared to men [ 35 ]. Furthermore, a positive correlation between DHT levels at birth and higher CD5 + B cells is determined in men in comparison to women [ 82 ]( Table 1 ).…”
Section: Adaptive Immune Systemmentioning
confidence: 99%
“…Restriction and downregulation of immune responses is fundamental to control inflammatory conditions and to sustain self-tolerance and is thus of particular importance in the prevention of autoinflammation and autoimmunity. To date, T regs which secret the anti-inflammatory cytokine IL-10 ( Martini et al, 2020 ; Tian et al, 2021 ) have been studied in the context of various cardiovascular diseases like atherosclerosis ( Meng et al, 2016 ) and also PH where they have beneficial effect in terms of disease progression, implying that T reg deficiency or malfunction might trigger disease aggravation ( Martini et al, 2020 ; Tian et al, 2021 ; Figure 1 ).…”
Section: Adaptive Immunitymentioning
confidence: 99%
“…Some cells can promote whereas some can inhibit the occurrence and development of cardiovascular diseases (Figure 4). (Gisterå and Hansson, 2017;Tabas and Lichtman, 2017;Albany et al, 2019;Wu et al, 2019;Martini et al, 2020;Saigusa et al, 2020;Varricchi et al, 2020;Ferrari et al, 2021) Current treatment strategy for ICIrelated cardiotoxicity…”
Section: Composition and Function Of The Cardiovascular Immune Systemmentioning
confidence: 99%