2019
DOI: 10.1111/imm.13088
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Regulatory T cells in cancer: where are we now?

Abstract: Summary There have been substantial strides forward in our understanding of the contribution of regulatory T (Treg) cells to cancer immunosuppression. In this issue, we present a series of papers highlighting emerging themes on this topic relevant not only to our understanding of the fundamental biology of tumour immunosuppression but also to the design of new immunotherapeutic approaches. The substantially shared biology of CD4+ conventional T (Tconv) and Treg cells necessitates a detailed understanding of th… Show more

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Cited by 16 publications
(23 citation statements)
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“…High concentrations of ROS induce also specific alterations in TCR signaling, including conformational changes of TCR‐ζ and the tyrosine kinase LCK, thereby reducing phosphorylation and calcium flux, with consequent suppression of antigen‐mediated Tconv cell responses . The difficulty of remodeling lymphocytes with these functional defects could explain the failure of immunotherapy noted by Gallimore et al …”
Section: Highlighting the Role Of Energy/oxidative Metabolic Changesmentioning
confidence: 99%
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“…High concentrations of ROS induce also specific alterations in TCR signaling, including conformational changes of TCR‐ζ and the tyrosine kinase LCK, thereby reducing phosphorylation and calcium flux, with consequent suppression of antigen‐mediated Tconv cell responses . The difficulty of remodeling lymphocytes with these functional defects could explain the failure of immunotherapy noted by Gallimore et al …”
Section: Highlighting the Role Of Energy/oxidative Metabolic Changesmentioning
confidence: 99%
“…The crucial contribution of regulatory T (Treg) cells to cancer immunosuppression, and their role in immunotherapy, has been extensively reviewed …”
Section: Introductionmentioning
confidence: 99%
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