Regulatory T cells in pregnancy

Chaouat, Gérard; Voisin, G A

doi:10.1016/0008-8749(81)90312-9

Cited by 22 publications

(1 citation statement)

References 55 publications

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“…We believe that leukocyte transfusions from third-party donors to a wife who clinically aborts with the same husband provide a barrage of TLX incompatibility antigens that stimulate her to mount protecting responses, such as blocking factors (Jeannet et al 1977) and suppressor eells (Chaouat & Voisin 1980), which disallow rejection of an implanted blastocyst by uterine immune cells. The basis of such protection must depend upon cross-reactivity with paternal allotype as a result of the large number of donors and frequency of leukocyte transfusions used in our programme of therapy.…”

Section: Discussionmentioning

confidence: 99%

Prevention of Recurrent Spontaneous Abortions by Leukocyte Transfusions

1985

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One hundred and thirty-nine couples referred because of recurrent abortions with no obvious cause were assessed for genetic similarity using the HLA major histocompatibility system. Comparison with 103 fertile control couples demonstrated that a much higher proportion of couples in the abortion group shared two or more HLA antigens. Using this criterion, 44 wives out of the 139 couples referred, when compared with a child-bearing group, appeared to share a greater than expected number of histocompatibility antigens and were therefore considered suitable for treatment. Twenty-eight wives have received treatment with white cell infusions from erythrocyte-compatible donors and so far they have delivered 17 babies plus 2 second babies. Another 3 wives are pregnant beyond their previous dates for abortions (1 first and 2 second pregnancies). There have been 5 failures (4 first pregnancy and 1 second pregnancy); one of these was treated a second time and has now successfully delivered. Seven couples are awaiting conception. Of the patients who have become pregnant, 81.5% have had successful deliveries. No adverse transfusion reactions have been observed.

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Section: Discussionmentioning

confidence: 99%