Organ Donation and Transplantation 2021
DOI: 10.5772/intechopen.94362
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Regulatory T Cells in the Mosaic of Liver Transplantation Tolerance

Abstract: The success of transplantation depends on multiple factors, but the establishment of immune tolerant milieu is of critical importance. Hepatic environment consists of different cellular populations with prominent capacity to tolerate a huge range of antigens. Among them, regulatory T cells (Tregs) play an important role. They control the strength of immune reactions against non-self antigens and were shown to have an impact on the establishment of immune tolerance in the post-transplantation period. Furthermor… Show more

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Cited by 1 publication
(2 citation statements)
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References 155 publications
(159 reference statements)
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“…Studies have been reported that immunosuppression in LT patients can effectively reduce the hyperinflammatory in the clinical course of COVID-19 and potentially serve as a protecting factor to prevent cytokine release syndrome [5]. Innate and adaptive immunity may be altered in LT recipients taking combinations of immunosuppressive drugs for an extended period [6]. In the present study, serially decreasing HGB and HCT were observed among the LT recipients pre and post COVID-19 infection and these decreases were statistically significant.…”
Section: Resultssupporting
confidence: 58%
See 1 more Smart Citation
“…Studies have been reported that immunosuppression in LT patients can effectively reduce the hyperinflammatory in the clinical course of COVID-19 and potentially serve as a protecting factor to prevent cytokine release syndrome [5]. Innate and adaptive immunity may be altered in LT recipients taking combinations of immunosuppressive drugs for an extended period [6]. In the present study, serially decreasing HGB and HCT were observed among the LT recipients pre and post COVID-19 infection and these decreases were statistically significant.…”
Section: Resultssupporting
confidence: 58%
“…As a low number of studies divided recipients in subgroups regarding interval after transplantation, there might be statistical power issues analyzing this effect of post-transplantation time. The largest part of the studies could not find an independent association between type of baseline immunosuppression and mortality or severe disease (see [6]). However, the short follow-up time in most of the studies might confound this, clarifying that long follow-up studies are needed to evaluate the modifications on graft function.…”
Section: Resultsmentioning
confidence: 99%