2019
DOI: 10.1111/imm.13060
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Regulatory T‐cells promote pulmonary repair by modulating T helper cell immune responses in lipopolysaccharide‐induced acute respiratory distress syndrome

Abstract: Summary Acute respiratory distress syndrome (ARDS) induces a strong local infiltration of regulatory T‐cells (Tregs) in the lungs. However, at present, there remains a lack of adequate evidence showing the direct effect of Tregs on pulmonary repair and the related mechanisms of ARDS. Therefore, in this project, we studied the impact of Tregs on lipopolysaccharide (LPS)‐induced ARDS and pulmonary inflammation. Surprisingly, we found that depletion of Tregs by injection of PC61 anti‐CD25 antibody not only interf… Show more

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Cited by 34 publications
(31 citation statements)
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“…(1) Overexpressing TGFβ1 inhibited the proliferation of mMSCs during days 5-7 but had no effect on their differentiation or migration. 2 As an important part of adaptive immunity, T cell immunity is involved in the development of ARDS 21,22 . Several studies have shown that speci c regulation of T cell differentiation could improve the immunity and in ammation state of ARDS in animal models, resulting in prognosis improvement 21,23,24 .…”
Section: Discussionmentioning
confidence: 99%
“…(1) Overexpressing TGFβ1 inhibited the proliferation of mMSCs during days 5-7 but had no effect on their differentiation or migration. 2 As an important part of adaptive immunity, T cell immunity is involved in the development of ARDS 21,22 . Several studies have shown that speci c regulation of T cell differentiation could improve the immunity and in ammation state of ARDS in animal models, resulting in prognosis improvement 21,23,24 .…”
Section: Discussionmentioning
confidence: 99%
“…Tregs have essential roles in both health and disease, having both protective effects in multiple disease states (autoimmune disease, inflammatory bowel disease, and ANCA vasculitis) and deleterious effects on immune regulation in cancer [ 5 7 ]. In experimental models of ALI, Tregs increase following lung injury and play an important role in resolution by suppressing inflammation, promoting epithelial and endothelial cell repair, and reducing fibrosis [ 8 12 ]. Tregs are present in the bronchoalveolar compartment in humans with ARDS [ 9 , 13 15 ], though their kinetics and role during recovery following ARDS in humans have yet to be defined.…”
Section: Introductionmentioning
confidence: 99%
“…(1) Overexpressing TGFβ1 inhibited the proliferation of mMSCs during days 5-7 but had no effect on their differentiation or migration. 2 As an important part of adaptive immunity, T cell immunity is involved in the development of ARDS 21,22 .…”
Section: Discussionmentioning
confidence: 99%