Regulatory T cells suppress skin inflammation in the imiquimod-induced psoriasis-like mouse model

Choi, Chong Won; Kim, Bo Ri; Yang, Seoyun; Kim, Yejin; Kang, Jae Seung; Youn, Sang Woong

doi:10.1016/j.jdermsci.2020.04.008

Cited by 6 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Treg cells are the best characterised immunosuppressing cell. The deletion of Treg cells in mice with imiquimod induced psoriasis phenotypes leads to increased infiltration of γδ, CD4+ and CD8+ T cells, the increased presence of IL-17 and TNF-α, as well as increased severity of skin lesions [ 145 , 146 ]. Further, several treatments of psoriasis operate by stimulating the proliferation and action of Treg cells, highlighting their importance in pathogenesis [ 147 , 148 ].…”

Section: Barrier Aberration In Psoriasismentioning

confidence: 99%

Skin Barrier Dysregulation in Psoriasis

Andreas

Bereza-Malcolm

Lynch

et al. 2021

IJMS

View full text Add to dashboard Cite

The skin barrier is broadly composed of two elements—a physical barrier mostly localised in the epidermis, and an immune barrier localised in both the dermis and epidermis. These two systems interact cooperatively to maintain skin homeostasis and overall human health. However, if dysregulated, several skin diseases may arise. Psoriasis is one of the most prevalent skin diseases associated with disrupted barrier function. It is characterised by the formation of psoriatic lesions, the aberrant differentiation and proliferation of keratinocytes, and excessive inflammation. In this review, we summarize recent discoveries in disease pathogenesis, including the contribution of keratinocytes, immune cells, genetic and environmental factors, and how they advance current and future treatments.

show abstract

Section: Barrier Aberration In Psoriasismentioning

confidence: 99%

Skin Barrier Dysregulation in Psoriasis

Andreas

Bereza-Malcolm

Lynch

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…Regulatory T cells (Treg) are the most characteristic immunosuppressive cells. Suppression of Tregs results in increased penetration of γδ, CD4+, and CD8+T cells, an increased presence of IL-17 and tumor necrosis factor-α, and increased severity of skin lesions ( 165 ). Regulatory B cells (Breg), which exert immunosuppressive effects by producing the anti-inflammatory cytokine IL-10, was reduced in the circulation of patients with psoriasis ( 166 ).…”

Section: Ige Is a Link Or Epiphenomena For Atopic Dermatitis And Psor...mentioning

confidence: 99%

Elevation of IgE in patients with psoriasis: Is it a paradoxical phenomenon?

Shi

Liu²,

Xiong

et al. 2022

Front. Med.

View full text Add to dashboard Cite

Immunoglobulin E (IgE) elevation is a hallmark of allergic conditions such as atopic dermatitis (AD). The pathogenesis of AD is typically associated with high levels of IL-4 and IL-13 produced by activated T helper 2 (Th2) cells. Psoriasis, on the other hand, is an inflammatory skin disease mainly driven by Th17 cells and their related cytokines. Although the immunopathologic reactions and clinical manifestations are often easily distinguished in the two skin conditions, patients with psoriasis may sometimes exhibit AD-like manifestations, such as elevated IgE and persistent pruritic lesions. Given the fact that the effective T cells have great plasticity to re-differentiate in response to innate and environmental factors, this unusual skin condition could be a consequence of a cross-reaction between distinct arms of T-cell and humoral immunity. Here we review the literature concerning the roles of IgE in the development of AD and psoriasis, showing that elevated IgE seems to be an important indicator for this non-typical psoriasis.

show abstract

“…The conversion of Treg cells to IL-17A-secreting cells that have lost their suppressive function has been shown in several autoimmune diseases including psoriasis ( 30 – 32 ). In animal models of psoriasis, depletion of Treg cells results in increased disease severity ( 33 – 35 ), highlighting their crucial role in disease regulation. Despite this knowledge, there are currently no treatments available specifically targeting Treg cell augmentation in psoriasis.…”

Section: Introductionmentioning

confidence: 99%

Alleviating psoriatic skin inflammation through augmentation of Treg cells via CTLA-4 signaling peptide

Lee,

Nam,

Kim

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

Psoriasis is a chronic inflammatory skin disease characterized by hyperplasia of keratinocytes and immune cell infiltration. The IL-17-producing T cells play a key role in psoriasis pathogenesis, while regulatory T (Treg) cells are diminished during psoriatic inflammation. Current psoriasis treatments largely focus on IL-17 and IL-23, however, few studies have explored therapeutic drugs targeting an increase of Treg cells to control immune homeostasis. In this study, we investigated the effects of a cytotoxic T lymphocyte antigen-4 (CTLA-4) signaling peptide (dNP2-ctCTLA-4) in Th17, Tc17, γδ T cells, Treg cells in vitro and a mouse model of psoriasis. Treatment with dNP2-ctCTLA-4 peptide showed a significant reduction of psoriatic skin inflammation with increased Treg cell proportion and reduced IL-17 production by T cells, indicating a potential role in modulating psoriatic skin disease. We compared dNP2-ctCTLA-4 with CTLA-4-Ig and found that only dNP2-ctCTLA-4 ameliorated the psoriasis progression, with increased Treg cells and inhibited IL-17 production from γδ T cells. In vitro experiments using a T cell-antigen presenting cell co-culture system demonstrated the distinct mechanisms of dNP2-ctCTLA-4 compared to CTLA-4-Ig in the induction of Treg cells. These findings highlight the therapeutic potential of dNP2-ctCTLA-4 peptide in psoriasis by augmenting Treg/Teff ratio, offering a new approach to modulating the disease.

show abstract

Regulatory T cells suppress skin inflammation in the imiquimod-induced psoriasis-like mouse model

Cited by 6 publications

References 10 publications

Skin Barrier Dysregulation in Psoriasis

Skin Barrier Dysregulation in Psoriasis

Elevation of IgE in patients with psoriasis: Is it a paradoxical phenomenon?

Alleviating psoriatic skin inflammation through augmentation of Treg cells via CTLA-4 signaling peptide

Contact Info

Product

Resources

About