Rehabilitation in Dementia Care

Hurzuk, Saadiya; Ambali, Anand P.

doi:10.1007/978-981-16-3864-0_11

Cited by 1 publication

(1 citation statement)

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“…The cerebrovascular lesions with ischemia in the septohippocampal region can cause the cognition deterioration and progression of VaD [5,6]. Moreover, VaD does not only cause memory loss; VaD patients also experience deterioration of attention and compromised executive function, such as difficulty in problem-solving, impairment of task execution, inability to plan, disorientation, and poor judgment [7].…”

Section: Introductionmentioning

confidence: 99%

Ameliorative Processes of Beta-Carotene in Streptozotocin-Induced Diabetic Vascular Dementia in Rats

Lim

Muthuraman

2022

Processes

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Beta-carotene (BC) is a precursor of vitamin A and an excellent antioxidant. It protects the vascular system. Vascular dementia (VaD) is one of the aging disorders causing memory dysfunction. The available medicines for the management of VaD are limited. The present study aimed to evaluate the ameliorative effect of BC in streptozotocin (STZ)-induced diabetic VaD in rats. Diabetic VaD was induced through the administration of nicotinamide (NA, 50 mg/kg; i.p.) and STZ (50 mg/kg; i.p.). The test compound BC (50 and 100 mg/kg; p.o.) and reference compound donepezil (1 mg/kg; p.o.) were administered for 15 consecutive days. Cognitive changes were assessed by transfer latency (TL) using the elevated plus maze (EPM) test. The changes in acetylcholinesterase (AChE) activity were estimated in the septohippocampal system of rat brains. The administration of STZ caused significant changes in cognitive functions (increased TL) as compared to the normal group. BC ameliorated the anxiety-related cognitive behavior and neurotransmitter (elevated AChE) changes provoked by diabetic VaD. Therefore, BC could be a potential therapeutic candidate in the management of VaD.

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Section: Introductionmentioning

confidence: 99%