Rehabilitation of patients after CAR T-cell therapy. Experiences on 5 patients

Kiefer, Thomas; Lüders, Christian; Völler, Heinz; Daeschlein, Georg

doi:10.1016/j.trim.2022.101770

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…So autologous transplantation is better than allogenic transplantation. 22 Allogenic transplantation is not a standard treatment for myeloma (cancer). It may be done as part of clinical trials.…”

Section: Allogenic Transplantationmentioning

confidence: 99%

Leveraging electronic health records and stem cell transplants: a review

Teja,

Gundimeda,

Kolipakula

et al. 2023

Int J Sci Rep

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Biomedical informatics is a burgeoning multidisciplinary field that seeks to optimize the utilization of biomedical data, information, and knowledge for the purposes of scientific research, inquiry, problem-solving, and decision-making, all with the overarching objective of enhancing human health and well-being. Information, informatics, and its applications are used in organ transplantations, such as stem cell transplantation programs, and in programs that directly change disorders. So, many hospitals can maintain EMRs (Electronic medical records), but few are supporting C programs. So, using informatics, we introduced software and programs to run these SCT applications in a very short period of time without any effect.

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Section: Allogenic Transplantationmentioning

confidence: 99%

Leveraging electronic health records and stem cell transplants: a review

Teja,

Gundimeda,

Kolipakula

et al. 2023

Int J Sci Rep

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Fluctuation of physical function during chimeric antigen receptor T‐cell therapy during rehabilitation intervention: Real‐world data and risk factor analyses

Hamada,

Arai,

Kitawaki

et al. 2024

eJHaem

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IntroductionPatients undergoing chimeric antigen receptor (CAR) T‐cell therapy face prolonged treatment timelines and are prone to cytokine release syndrome (CRS) and immune effector cell‐associated neurotoxicity syndrome (ICANS) after infusion. Disabilities in physical function and the importance of rehabilitation during CAR‐T‐cell therapy to maintain physical function have been poorly documented.MethodWe performed a retrospective cohort study to assess changes in exercise tolerance via differences in a 6‐min‐walking distance (Δ6MWD) and factors influencing it.ResultsA total of 77 patients who underwent rehabilitation during CAR‐T‐cell therapy were enrolled, and their 6MWD was 450 m (median, range 180–705 m) before and 450.5 m (107.0–735.0 m) 30 days after CAR‐T treatment. No significant alteration in Δ6MWD was observed overall (11.0 m, 95% confidence interval, −56.1 to 88.2 m). Multiple regression analyses indicated that age (over vs. under 65 years) revealed no notable differences in Δ6MWD (20 vs. 10 m), while ΔHb (β = 0.24, p = 0.03), moderate/severe CRS (grade 1 with continuous fever or grade ≥2; β = −0.25, p = 0.03), and ICANS (any grade; β = −0.22, p = 0.04) were significantly associated with lower Δ6MWD.ConclusionThis real‐world study indicated that CAR‐T‐cell therapy is less likely to reduce physical function even in older patients if rehabilitation is properly performed, whereas CRS and ICANS can be risk factors to deprive exercise tolerance.

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