Stroke is the main cause of disability in the Russian population and produces persistent maladaptation of patients [1][2][3]. There are more than a million invalids in Russia due to acute stroke. The level of disability one year after stroke in Russia is 76-85%, no more than 20% of patients returning to work, and 20-30% remaining profoundly disabled for the rest of their lives [4,5]. The cost per stroke patient to the Russian Federation is 127,000 rubles [6,7]. These data provide evidence for the need to fi nd ways of im proving the rehabilitation of stroke patients.One important and as yet unresolved problem in the rehabilitation of stroke patients is that of restorative treatment in patients with neglect syndrome (NS), which some investigators believe is an important factor delaying adequate recovery of neurological functions [8][9][10][11]. NS is characterized by loss of the patient's ability to respond to stimulation or perceive information on the side opposite the lesioned hemisphere. The patient is unable to observe a stimulus, respond to it, or focus attention on it [12]. Observation of patients with NS creates the impression that they behave as though space on the left (usually) side does not exist, and sometimes as though their body does not have a left side [13].The mechanism of NS remains incompletely understood. Its development cannot be explained only in terms of sensory or motor defi cit. Disorders of brain functions in unilateral NS occur at a higher level, where attention and its associated intellectual functions -memory and planning of motor acts -are controlled. Data reported by a number of authors show that NS occurs in large lesions of the posterior (parietal or parietal-occipital) areas of the right hemisphere [8,13]. It is also believed that the development of Objective. To evaluate the use of different treatment systems to increase the effi cacy of the rehabilitation of patients with neglect syndrome (NS) after stroke. Materials and methods. The effects of observing a protocol for managing patients with NS and using Ceraxon (citicoline) on the extent of recovery of neurological functions, the level of daily adaptation, and elimination of NS were studied in stroke patients. Treatment results from 120 patients were analyzed. The extent of restoration of functions was assessed using the Lindmark scale, the level of daily adaptation using the Barthel scale and the Merton and Sutton scale, the state of cognitive functions using the MMSE and the Frontal Assessment Battery, and psychoemotional status using the Beck questionnaire. Treatment effi cacy was also evaluated in terms of the absence of the characteristic signs of NS. Results and conclusion. These studies showed that complex rehabilitation following the protocol for managing patients with NS and Ceraxon signifi cantly increased rehabilitation effi cacy in this group of patients.