Rehabilitation Treatment and Progress of Traumatic Brain Injury Dysfunction

Dang, Baoqi; Chen, Wenli; He, Weichun; Chen, Gang

doi:10.1155/2017/1582182

Cited by 104 publications

(86 citation statements)

References 71 publications

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“…To date, more than 1000 clinical trials on TBI have been registered on clinicaltri als.gov. In spite of the immense efforts on the treatment of TBI made in the past few decades, few effective therapies for TBI are available [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Dual roles of astrocytes in plasticity and reconstruction after traumatic brain injury

et al. 2020

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Traumatic brain injury (TBI) is one of the leading causes of fatality and disability worldwide. Despite its high prevalence, effective treatment strategies for TBI are limited. Traumatic brain injury induces structural and functional alterations of astrocytes, the most abundant cell type in the brain. As a way of coping with the trauma, astrocytes respond in diverse mechanisms that result in reactive astrogliosis. Astrocytes are involved in the physiopathologic mechanisms of TBI in an extensive and sophisticated manner. Notably, astrocytes have dual roles in TBI, and some astrocyte-derived factors have double and opposite properties. Thus, the suppression or promotion of reactive astrogliosis does not have a substantial curative effect. In contrast, selective stimulation of the beneficial astrocytederived molecules and simultaneous attenuation of the deleterious factors based on the spatiotemporalenvironment can provide a promising astrocyte-targeting therapeutic strategy. In the current review, we describe for the first time the specific dual roles of astrocytes in neuronal plasticity and reconstruction, including neurogenesis, synaptogenesis, angiogenesis, repair of the blood-brain barrier, and glial scar formation after TBI. We have also classified astrocyte-derived factors depending on their neuroprotective and neurotoxic roles to design more appropriate targeted therapies.

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Section: Introductionmentioning

confidence: 99%

Dual roles of astrocytes in plasticity and reconstruction after traumatic brain injury

et al. 2020

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“…30 Thus, it is urgent need to find a drug that effectively inhibits the pathological development of TBI in the early stage. 30 Thus, it is urgent need to find a drug that effectively inhibits the pathological development of TBI in the early stage.…”

Section: Discussionmentioning

confidence: 99%

Dl‐3n‐butylphthalide improves traumatic brain injury recovery via inhibiting autophagy‐induced blood‐brain barrier disruption and cell apoptosis

et al. 2019

J Cellular Molecular Medi

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Blood-brain barrier (BBB) disruption and neuronal apoptosis are important pathophysiological processes after traumatic brain injury (TBI). In clinical stroke, Dl-3nbutylphthalide (Dl-NBP) has a neuroprotective effect with anti-inflammatory, anti-oxidative, anti-apoptotic and mitochondrion-protective functions. However, the effect and molecular mechanism of Dl-NBP for TBI need to be further investigated.Here, we had used an animal model of TBI and SH-SY5Y/human brain microvascular endothelial cells to explore it. We found that Dl-NBP administration exerts a neuroprotective effect in TBI/OGD and BBB disorder, which up-regulates the expression of tight junction proteins and promotes neuronal survival via inhibiting mitochondrial apoptosis. The expressions of autophagy-related proteins, including ATG7, Beclin1 and LC3II, were significantly increased after TBI/OGD, and which were reversed by Dl-NBP treatment both in vivo and in vitro. Moreover, rapamycin treatment had abolished the effect of Dl-NBP for TBI recovery. Collectively, our current studies indicate that Dl-NBP treatment improved locomotor functional recovery after TBI by inhibiting the activation of autophagy and consequently blocking the junction protein loss and neuronal apoptosis. Dl-NBP, as an anti-inflammatory and anti-oxidative drug, may act as an effective strategy for TBI recovery.Fangfang Wu and Ke Xu contributed equally to this work. | 1221WU et al.

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“…Advancements in medical management following acquired brain injury (ABI) have resulted in an increasing number of individuals living with persistent cognitive and linguistic deficits (Dang et al . , Tabish and Syed ). ABI frequently results in long‐term difficulty in the production of spoken discourse, which has direct consequences for social interaction.…”

Section: Introductionmentioning

confidence: 96%

Discourse and cognition in speakers with acquired brain injury (ABI): a systematic review

Hill

Claessen

Whitworth

et al. 2018

Intl J Lang & Comm Disor

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This review revealed present, yet heterogeneous, relationships between cognitive and discourse deficits in speakers with ABI. Associations were interpreted in light of a well-established model of discourse processing. Greater comparison across studies would have been facilitated by a standard nomenclature in relation to cognitive constructs and standardized discourse assessment. Future research should explore the influence of injury- and participant-related factors on discourse-cognitive relationships. The lack of information on conversational discourse and paediatric ABI limits the generalizability of this review to daily interaction following ABI. While applicable across the lifespan, in-depth investigation of discourse following ABI in childhood and adolescence is a priority due to complex changes in language and cognition, and the potential for impairments profoundly impact social, emotional and academic progression into adulthood. Given the centrality of remediating cognitive-communication difficulties in ABI, the interrelationships between discourse and cognition should retain a critical focus of research. This will inform clinical management and future research with this population. Findings have implications for our theoretical understanding of discourse and the nature of its breakdown in ABI.

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Rehabilitation Treatment and Progress of Traumatic Brain Injury Dysfunction

Cited by 104 publications

References 71 publications

Dual roles of astrocytes in plasticity and reconstruction after traumatic brain injury

Dual roles of astrocytes in plasticity and reconstruction after traumatic brain injury

Dl‐3n‐butylphthalide improves traumatic brain injury recovery via inhibiting autophagy‐induced blood‐brain barrier disruption and cell apoptosis

Discourse and cognition in speakers with acquired brain injury (ABI): a systematic review

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