“…Both have advantages and limitations, such as the high preservation cost of allogeneic transplants, the possibility of exogenous diseases and immune solid responses caused by allogenic antigens, and the limited availability of raw materials for autologous transplants. , The field of microfracture self-healing is still in early development, and further research is required to prove its efficacy. Stem cell therapy delivered through intravascular injection, intra-articular injection, or cell transplantation is also a promising alternative, requiring additional long-term studies to determine its efficacy and safety. , Cartilage tissue engineering, which involves the use of seed cells, engineered scaffolds, and cell growth factors, is a highly researched area ,as it provides an unlimited source of repair materials. , However, the hyaline cartilage produced by this approach may not withstand the stress of repeated joint movements as well as normal cartilage. , Therefore, there is a continuous demand for efficient methods to augment chondrocyte proliferation.…”