Rehmanniae Radix-Induced apoptosis via inhibition of PI3K/AKT/mTOR signaling pathways in human hepatocellular carcinoma cell lines SMMC-7721

Cai, Lin; Liao, Bo-nian; Luo, Fangli; Zhang, Shu; Deng, Zhengwan

doi:10.4103/pm.pm_147_21

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…Thus, the excessive ROS generation in renal epithelial cells treated with COM crystals is intrinsically intertwined with ER damage alongside the perturbations to mitochondria. ER stress is characterized by the accumulation of misfolded and unfolded proteins within the ER, the disruption of calcium equilibrium, the activation of unfolded protein responses, ER overload reactions, and Caspase 12-mediated apoptotic pathways [ 50 ]. In this study, we demonstrated that Nano-COM crystals substantially reduced ER Ca 2+ ion levels ( Figure 5 B) and caused structural disarray within the ER ( Figure 5 A).…”

Section: Discussionmentioning

confidence: 99%

“…In this study, we demonstrated that Nano-COM crystals substantially reduced ER Ca 2+ ion levels ( Figure 5 B) and caused structural disarray within the ER ( Figure 5 A). Furthermore, Liao et al [ 50 ] observed a pronounced elevation in the expression of ER stress markers, such as GRP78, CHOP, and Caspase 12 in a model of heightened ER stress activation. Our study also unveiled a noteworthy augmentation in the expression of Caspase-12 and CHOP concurrent with the onset of apoptosis ( Figure 6 and Figure 7 ).…”

Section: Discussionmentioning

confidence: 99%

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Sulfated Laminarin Polysaccharides Reduce the Adhesion of Nano-COM Crystals to Renal Epithelial Cells by Inhibiting Oxidative and Endoplasmic Reticulum Stress

He,

Wang,

et al. 2024

Pharmaceuticals

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Purpose: Adhesion between calcium oxalate crystals and renal tubular epithelial cells is a vital cause of renal stone formation; however, the drugs that inhibit crystal adhesion and the mechanism of inhibition have yet to be explored. Methods: The cell injury model was constructed using nano-COM crystals, and changes in oxidative stress levels, endoplasmic reticulum (ER) stress levels, downstream p38 MAPK protein expression, apoptosis, adhesion protein osteopontin expression, and cell–crystal adhesion were examined in the presence of Laminarin polysaccharide (DLP) and sulfated DLP (SDLP) under protected and unprotected conditions. Results: Both DLP and SDLP inhibited nano-COM damage to human kidney proximal tubular epithelial cell (HK-2), increased cell viability, decreased ROS levels, reduced the opening of mitochondrial membrane permeability transition pore, markedly reduced ER Ca2+ ion concentration and adhesion molecule OPN expression, down-regulated the expression of ER stress signature proteins including CHOP, Caspase 12, and p38 MAPK, and decreased the apoptosis rate of cells. SDLP has a better protective effect on cells than DLP. Conclusions: SDLP protects HK-2 cells from nano-COM crystal-induced apoptosis by reducing oxidative and ER stress levels and their downstream factors, thereby reducing crystal–cell adhesion interactions and the risks of kidney stone formation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sulfated Laminarin Polysaccharides Reduce the Adhesion of Nano-COM Crystals to Renal Epithelial Cells by Inhibiting Oxidative and Endoplasmic Reticulum Stress

He,

Wang,

et al. 2024

Pharmaceuticals

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Jieduquyuziyin prescription alleviates lupus development via inhibiting neddylation pathway to promote Bim-induced apoptosis of double negative T cells

Li,

Duan,

Wang

et al. 2025

Journal of Ethnopharmacology

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Herbal Medicine-derived Compounds for the Prevention and Treatment of Hepatocellular Carcinoma

Farzaneh

2022

CCTR

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Hepatocellular carcinoma (HCC) is the second malignancy worldwide. Dysregulation of various signaling pathways has been detected in HCC. Recent investigations have suggested a new approach for the prevention and treatment of HCC with herbal drugs. The anticancer effects of herbal drugs can be evaluated in animal models or HCC cell lines. Various molecular mechanisms and signaling pathways such as TGF-β, Wnt/β-catenin, SHH, Notch, Hippo, PI3K, and VEGF have been found to induce and promote carcinogenesis of HCC. Herbal drugs can target the signaling pathways in HCC and trigger apoptosis, suppress proliferation, and tumor growth. Molecularly targeted therapies using herbal drugs can be novel therapeutic strategies against HCC. This study provides the latest findings on using herbal medicine-derived compounds in the control of HCC.

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Rehmanniae Radix-Induced apoptosis via inhibition of PI3K/AKT/mTOR signaling pathways in human hepatocellular carcinoma cell lines SMMC-7721

Cited by 3 publications

References 19 publications

Sulfated Laminarin Polysaccharides Reduce the Adhesion of Nano-COM Crystals to Renal Epithelial Cells by Inhibiting Oxidative and Endoplasmic Reticulum Stress

Sulfated Laminarin Polysaccharides Reduce the Adhesion of Nano-COM Crystals to Renal Epithelial Cells by Inhibiting Oxidative and Endoplasmic Reticulum Stress

Jieduquyuziyin prescription alleviates lupus development via inhibiting neddylation pathway to promote Bim-induced apoptosis of double negative T cells

Herbal Medicine-derived Compounds for the Prevention and Treatment of Hepatocellular Carcinoma

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