New advancements in biotechnology has made many biotechnological products such as yeast, bacteria, vitamins, enzymes, proteins, carbohydrates, antibiotics, fungi, lysine, blood, plasma, realize in industry and commercial market. Most of these products appear in the form of liquid, suspension, or paste, which require refrigeration for storage. Refrigeration however limits the widespread application of the products mentioned above, as the operating costs and handling of frozen products is high and difficult. As such, dehydration and drying can be deployed to reduce the handling cost, while prolonging the shelf life, retaining the active ingredients activity, maintaining the cell survival and vitality, as well as its physical, textural, sensory, and optical properties. Biotechnological products are heat sensitive. Conventional drying methods for nonbiotechnological products such as hot air drying may damage and denature the product, destroy the cell and active ingredients, cause case hardening and browning. Over the years, freeze‐drying is the most common method used in the drying of some of the biotechnological products mentioned above. However, the operating cost and the drying time of freeze‐drying are comparatively high. As oil prices are skyrocketing and there is no sign that the price will ease in the near future, researchers and scientists have designed, tested, and improved various drying methods in order to improve drying efficiency and performance. This article discusses various conventional drying methods, which are common to the drying of biotechnological products, and describes various advanced drying technologies that give improvements and better performance with reference to drying strategy, drying medium, handling of drying materials, and mode of heat input. These include intermittent drying, pulse combustion drying, impinging stream drying, cyclic pressure vacuum drying, spray‐freeze‐drying, atmospheric freeze‐drying, vacuum fluidized bed drying, low‐pressure spray drying, superheated steam drying, heat pump drying, inert medium drying, supercritical fluid drying, sorption drying, spouted bed drying, jet spouted bed drying, vibrating fluidized bed drying, pulse fluidized bed drying, high electric field drying, and microwave drying. Recent research findings of these drying technologies are given as well.