Reimplantation of an extruded osteoarticular segment of the femur: Case series and in vitro study in a rat model

Li, Tao; Yang, Ze Z.; Peng, Ming; Zhou, Xiao; Liu, Zhi Y.; Rui, Bi; Li, Qi; Guo, Shang; Xiao, Ming; Wang, Jinwu

doi:10.1016/j.injury.2017.09.024

Cited by 6 publications

(4 citation statements)

References 27 publications

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“…We chose a similar treatment method to the few studies in the literature. [4,5] The success of our case, as with the previous cases reported, can be attributed to an intact periosteal bed and absence of infection. It is not possible to say that the over-healing in our case is related to the autoclaving of the segment, and it may be appropriate to conduct a histological examination.…”

Section: Discussionsupporting

confidence: 81%

“…[9] There are few studies in the literature on autoclaved bone autograft replacement after traumatic extrusion. Li et al [4] reported a successful replacement of extruded diaphyseal segments after autoclaving. Rao and Patil [10] reported a case of a 17-year-old male, involved in a motor vehicle accident, had a traumatic extrusion of the lower third of the diaphyseal segment of the left radius and a comminuted fracture of the distal third of the ulna.…”

Section: Discussionmentioning

confidence: 99%

“…An in vitro study in rats reported that a successful replacement of extruded diaphyseal segments after autoclaving. [4] However, there is no established protocol or consensus…”

mentioning

confidence: 99%

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Reconstruction of a traumatic femoral bone defect using the extruded diaphyseal segment after autoclave sterilization

Şahin

Durgut

Tugrul

2022

Jt Dis Relat Surg Case Rep

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on how to sterilize extruded bone segments in the literature. In this article, we report a case with open fracture in which the extruded bone fragment was implanted after it was autoclaved. CASE REPORTAn 18-year-old male who suffered a motorcycle accident was admitted to the emergency department. On physical examination, there were dermal abrasions on the left half of the face and left arm, as well as open fractures in the left femur and left tibia. According to the Gustilo-Anderson classification, the femur fracture was type III, and the tibia fracture was type II. Tetanus prophylaxis and antibiotic prophylaxis (first-generation cephalosporin) were administered to the patient in the emergency room.Radiographs revealed that an approximately 12 cm femoral bone segment was extruded from the 5 cm wound at the anterior thigh (Figure 1). It was thought that a longitudinal deforming force had

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

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Reconstruction of a traumatic femoral bone defect using the extruded diaphyseal segment after autoclave sterilization

Şahin

Durgut

Tugrul

2022

Jt Dis Relat Surg Case Rep

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“…Li et al reported successful reimplantation of an extruded osteoarticular segment of the femur in a rat model with sterilization by povidone–iodine scrub/orthopaedic antibiotic solution. 7 Similarly, Singhi et al described a reimplantation of an extruded metaphyseal segment of the distal femoral condyle following cleaning with copious saline and soaking in 10% povidone–iodine for 20 minutes in a 21-year-old male. 2 In some cases, hybrid sterilization methods have been used.…”

Section: Discussionmentioning

confidence: 99%

Reimplantation of a Large Extruded Segment of Tibia in an Open Fracture in a Pediatric Patient

Afshar

Tabrizi

2019

Surg J

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A 6-year-old boy presented with a Gustilo type IIIB open fracture on his left leg with a segment of bone loss in his tibia. The boy's attendants brought two bone fragments recovered from the scene of the accident. The extruded bones were a segment with a length of 5.5 cm and a cortical bone with a length of 4 cm. The extruded fragments were reimplanted after scrubbing with 10% povidone–iodine for 20 minutes, soaking in 2% chlorhexidine solution for 20 minutes, and rinsing with normal saline. Four months after the injury, the extruded fragments were incorporated in the callus of the fracture site and complete fracture union in appropriate alignment was achieved.

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Genetic Screening of Haploid Neural Stem Cells Reveals that Nfkbia and Atp2b4 are Key Regulators of Oxidative Stress in Neural Precursors

Nie,

Zhang,

Jin

et al. 2024

Advanced Science

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Neurological diseases are expected to become the leading cause of death in the next decade. Although little is known about it, the interaction between oxidative stress and inflammation is harmful to the nervous system. To find an advanced tool for neural genetics, mouse haploid neural stem cells (haNSCs) from the somite of chimeric mouse embryos at E8.5 is established. The haNSCs present a haploid neural progenitor identity for long‐term culture, promising to robustly differentiate into neural subtypes and being able to form cerebral organoids efficiently. Thereafter, haNSC mutants via a high‐throughput approach and screened targets of oxidative stress is generated using the specific mutant library. Deletion of Nfkbia (the top hit among the insertion mutants) reduces damage from reactive oxygen species (ROS) in NSCs exposed to H2O2. Transcriptome analysis revealed that Atp2b4 is upregulated significantly in Nfkbia‐null NSCs and is probably responsible for the observed resistance. Additionally, overexpression of Atp2b4 itself can increase the survival of NSCs in the presence of H2O2, suggesting that Atp2b4 is closely involved in this resistance. Herein, a powerful haploid system is presented to study functional genetics in neural lineages, shedding light on the screening of critical genes and drugs for neurological diseases.

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Reimplantation of an extruded osteoarticular segment of the femur: Case series and in vitro study in a rat model

Cited by 6 publications

References 27 publications

Reconstruction of a traumatic femoral bone defect using the extruded diaphyseal segment after autoclave sterilization

Reconstruction of a traumatic femoral bone defect using the extruded diaphyseal segment after autoclave sterilization

Reimplantation of a Large Extruded Segment of Tibia in an Open Fracture in a Pediatric Patient

Genetic Screening of Haploid Neural Stem Cells Reveals that Nfkbia and Atp2b4 are Key Regulators of Oxidative Stress in Neural Precursors

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