Reincident corneal epithelial inclusion cyst in a dog: a case report

Abstract

An unilateral corneal epithelial inclusion cyst (CEIC) in a 8-years-old female mixed Poodle is reported. The cyst had been observed for 60 days, was unique, not congenital and only one eye was involved. One year prior to the referral the dog was treated with antibiotics due to an ocular trauma caused by a fight with a cat. In the same eye, palpebral melanocytic tumor and corneal dystrophy were also observed. In order to remove the CEIC a superficial keratectomy was performed. Collagen contact lens and topical antibiotics were the medical treatment of choice. Fifteen month after surgery the dog was referred for recurrence of the CEIC. A second keratectomy and similar topical treatment was attempted again. A second recurrence 16 months after surgery has not been observed to the date. Cytology and histology analysis of the cyst confirmed the diagnosis of the CEIC. Microbiologic studies were also realized and Staphylococcus epidermidis was aisled twice in fifteen months. In this case a relapsing CEIC is reported associated to S. epidermidis contamination. Corneal dystrophy and palpebral melanoma were concomitant lesions, although no relations with the CEIC were concluded.

Corneal epithelial inclusion cysts in 12 dogs (13 eyes) from 2010 to 2019: A multicentric retrospective study

“…A search for “corneal epithelial inclusion cyst” performed in early 2020 in the PubMed Central database retrieved 7 single clinical cases description in dogs 1,4,6,19,21,24,25 and 2 clinical case series in 1990 2 and 1974 26 . Supplementary single cases were found in Ciência Rural, 3 Santa Maria, and Veterinárni Medicina 27 . An original single case was also presented on a poster at an ECVO meeting 20 .…”

Successful treatment of an unusually large corneal epithelial inclusion cyst using equine amniotic membrane in a dog

“…The case presented in this article is unusual because of the large size of the cyst, which covered half of the corneal surface. These diseases typically cause pain, discomfort, corneal edema, and uveitis 2,6,7 . In addition, corneal masses such as nodular fasciitis, papilloma, and histocytoma may be differential diagnoses in some cases 7 …”

“…Following corneal wounding, the excessive and inappropriate proliferation of epithelial cells may result in cyst formation 5,6 . Corneal epithelial inclusion cysts have been rarely reported in the veterinary literature and have a low incidence in domestic animals 1,2,5–7 . It is an important differential diagnosis for masses involving the cornea, and must be differentiated from bullous keratopathy, corneal abscess, corneal neoplasia, corneal dermoid, iris prolapse, and staphyloma formation 2,5 .…”

Clinical and diagnostic evaluation of intraocular expulsion of a corneal epithelial inclusion cyst in a dog

“…Corneal epithelial inclusion cysts are benign ophthalmic lesions that are rarely reported in veterinary literature. The lesions are formed by corneal epithelium becoming disorganized and displaced into the corneal stroma most commonly as a result of trauma . Following displacement, the epithelium will proliferate and continuously deposit desquamated cells into the center of the cyst .…”

“…The lesions are formed by corneal epithelium becoming disorganized and displaced into the corneal stroma most commonly as a result of trauma. [1][2][3][4][5][6][7][8][9] Following displacement, the epithelium will proliferate and continuously deposit desquamated cells into the center of the cyst. 1,3,4,10 These eye lesions have been previously reported in dogs, humans, llama, red deer, and a cat.…”