Reinfection of Severe Acute Respiratory Syndrome Coronavirus 2 in an Immunocompromised Patient: A Case Report

A case of SARS-CoV-2 reinfection in Ecuador

“…Cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection have been reported in Hong Kong, Belgium, the Netherlands, and the USA. 1 , 2 , 3 , 4 Here we report the first confirmed case of SARS-CoV-2 reinfection in Ecuador and South America. For full methodological details, see the appendix (pp 1, 2 ).…”

“…Increased severity of second SARSCoV2 infections has been reported previously: in a healthy man aged 25 years in Nevada, USA, 2 and in an immunocompromised woman aged 89 years in the Netherlands, which resulted in her death. 4 The protective immune response to SARSCoV2 infection is not fully understood; however, protection against severe disease has been shown in animal models and inferred in humans infected with the virus. 7 Interestingly, the antibody test performed during the first infection event showed the presence of specific antiSARSCoV2 IgM and no IgG.…”

COVID-19: Rethinking the Lockdown Groupthink

“…The seven published case reports of re-infection, four with symptoms [one requiring hospitalization, and one death in an immunocompromised 89 year old with few details reported], when 10% of the world population has likely been infected over the past 10 months cannot yet provide evidence that severe reinfection and contagion is at all common. [232][233][234][235][236][237] Regarding Manaus, the high seroprevalence likely reflected the special situation of a relatively homogeneous cohort of people in overcrowded low socioeconomic urban situations, with reliance on crowded long riverboat travel; now there seems to be a different demographic cohort of young wealthy individuals being exposed. [238][239][240] In addition, the peak seroprevalence in blood donors in Manaus was 51.8% in June, while another study of household seroprevalence in Manaus on May 14-21 found this to be 12.7% [the respective numbers for Sao Paulo were closer, at 6.9% and 3.3% in the two serosurveys].…”

Backward transmission of COVID-19 from humans to animals may propagate reinfections and induce vaccine failure

“…It is commonly accepted that, once already infected then cured, an individual is better protected against the infectious agent, yet this might not be true in some cases of rapidly mutating viruses such as COVID-19. At least seven cases of SARS-CoV-2 reinfections have been reported since the first case was reported in Hong Kong on August 24, 2020 (Larson et al 2020 ; Mulder et al 2020 ; Prado-Viviat et al 2020 ; Tillett et al 2020 ; To et al 2020 ; Torres et al 2020 ; Van Elslande et al 2020 ). Remarkably, in four cases, patients showed more severe symptoms than previous symptoms from their first infection, including one severe case where the individual died shortly after the reinfection.…”