Reinfection or reactivation: Genome‐based two distinct SNP profile of SARS‐CoV2 repositivity in an Indian case

Dhar, Mahesh Shanker; Vivekanand, A; Uppili, Bharathram; Tyagi, Nishu; Sharma, Pooja; Tiwari, Simmi; Srinivasan, RadhaKrishnan V; Marwal, Robin; Kanakan, Akshay; Khan, Azka; Pandey, Rajesh; Jais, Manoj; Gogoi, Sanjib; Shewale, Ajit; Nale, Tushar; Kabra, Sandhya; Faruq, Mohammed; Singh, Sujeet Kumar; Agrawal, Anurag; Rakshit, Partha

doi:10.1002/jmv.26948

Cited by 3 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In total, 35 articles describing the clinical courses of 60 unique individuals were identified that met the criteria. 7 – 14 , 18 – 43 An additional 114 articles were identified following abstract screening, but were not included in the analysis because they did not have sufficient sequencing results to conclude that the cases were reinfections. In total, 60 cases of verified reinfection were identified in this search.…”

Section: Resultsmentioning

confidence: 99%

Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection Cases Corroborated by Sequencing

Massachi

Donohue

Kelly

2021

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Evaluating the reinfection may offer some insight into areas for further investigation regarding durability of immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Sixty cases of reinfection with viral sequencing were identified in PubMed, Embase, Web of Science, and medRxiv before May 1, 2021.Episodes of infection were separated by a median of 116 days. Severity of illness was greater among individuals reinfected within 90 days of initial infection, no asymptomatic initial cases developed severe reinfection, nearly half of cases had suspected escape variants, and nearly all individual tested following reinfection were found to have detectable levels of anti-SARS-CoV-2 antibodies. This analysis is limited by the heterogeneous methods used among reports. Reinfection continues to be relatively rare. As the case rate presumably increases over time, this review will inform measurements to determine the natural history and causal determinants of reinfection in more rigorous observational cohort studies and other standardized surveillance approaches.

show abstract

Section: Resultsmentioning

confidence: 99%

Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection Cases Corroborated by Sequencing

Massachi

Donohue

Kelly

2021

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

show abstract

“…In the 36 studies (n = 51) [8-10, 32-37, 39, 43-45, 47-54, 56, 57, 59-62, 64-69, 71-73], which reported details of patients' symptoms during the first infection, these commonly included cough (30, 62.3%), fever (31, 58.5%), headache (20, 37.7%), diarrhea (13, 24.5%), sore throat (12, 22.6%), myalgia (12,22.6%), dyspnea (11,20.8%), rhinitis (9, 17%), fatigue (7, 13.2%), chills (6, 11.3%), anosmia (5, 9.4%), ageusia (5, 9.4%), malaise (4, 7.5%), chest pain (4, 7.5%), nasal congestion (4, 7.5%), odynophagia (4, 7.5%), nausea (3 5.7%), vomiting (2, 3.8%), anxiety (2, 3.8%), lethargy (2, 3.8%), panic attacks (1, 1.9%), sneezing (1, 1.9%), confusion (1, 1.9%), body pain (1, 1.9%), arthralgia (1, 1.9%), exertional tachycardia (1, 1.9%), dizziness (1, 1.9%), and arthromyalgia (1, 1.9%), and 10 (18.9%) patients [31,33,36,41,46,48,55,70] were asymptomatic.…”

Section: Symptoms Of Reinfected Patientsmentioning

confidence: 99%

Reinfection in patients with COVID-19: a systematic review

Ren

Zhou

Guo

et al. 2022

glob health res policy

View full text Add to dashboard Cite

Background With the continuation of the COVID-19 pandemic, some COVID-19 patients have become reinfected with the virus. Viral gene sequencing has found that some of these patients were reinfected by the different and others by same strains. This has raised concerns about the effectiveness of immunity after infection and the reliability of vaccines. To this end, we conducted a systematic review to assess the characteristics of patients with reinfection and possible causes. Methods A systematic search was conducted across eight databases: PubMed, Embase, Web of Science, The Cochrane Library, CNKI, WanFang, VIP and SinoMed from December 1, 2019 to September 1, 2021. The quality of included studies were assessed using JBI critical appraisal tools and Newcastle–Ottawa Scale. Results This study included 50 studies from 20 countries. There were 118 cases of reinfection. Twenty-five patients were reported to have at least one complication. The shortest duration between the first infection and reinfection was 19 days and the longest was 293 days. During the first infection and reinfection, cough (51.6% and 43.9%) and fever (50% and 30.3%) were the most common symptoms respectively. Nine patients recovered, seven patients died, and five patients were hospitalized, but 97 patients’ prognosis were unknown. B.1 is the most common variant strain at the first infection. B.1.1.7, B.1.128 and B.1.351 were the most common variant strains at reinfection. Thirty-three patients were infected by different strains and 9 patients were reported as being infected with the same strain. Conclusions Our research shows that it is possible for rehabilitated patients to be reinfected by SARS-COV-2. To date, the causes and risk factors of COVID-19 reinfection are not fully understood. For patients with reinfection, the diagnosis and management should be consistent with the treatment of the first infection. The public, including rehabilitated patients, should be fully vaccinated, wear masks in public places, and pay attention to maintaining social distance to avoid reinfection with the virus.

show abstract

“…The NGS-enabled genome sequencing has been instrumental in identifying the viral clades, lineages, and the role of non-synonymous mutations in altering the protein structure [ 15 ]. SARS-CoV-2 genome analysis can help us identify novel variants, reinfection cases, and also track the source of infection [ 16 ].Genomic surveillance has been instrumental to conclusively prove the incidences of re-infection. The identified mutations have been studied in detail for their role in immune escape through functional studies to enhance and elucidate the mechanism [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Clinico-Genomic Analysis Reveals Mutations Associated with COVID-19 Disease Severity: Possible Modulation by RNA Structure

et al. 2021

Self Cite

View full text Add to dashboard Cite

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) manifests a broad spectrum of clinical presentations, varying in severity from asymptomatic to mortality. As the viral infection spread, it evolved and developed into many variants of concern. Understanding the impact of mutations in the SARS-CoV-2 genome on the clinical phenotype and associated co-morbidities is important for treatment and preventionas the pandemic progresses. Based on the mild, moderate, and severe clinical phenotypes, we analyzed the possible association between both, the clinical sub-phenotypes and genomic mutations with respect to the severity and outcome of the patients. We found a significant association between the requirement of respiratory support and co-morbidities. We also identified six SARS-CoV-2 genome mutations that were significantly correlated with severity and mortality in our cohort. We examined structural alterations at the RNA and protein levels as a result of three of these mutations: A26194T, T28854T, and C25611A, present in the Orf3a and N protein. The RNA secondary structure change due to the above mutations can be one of the modulators of the disease outcome. Our findings highlight the importance of integrative analysis in which clinical and genetic components of the disease are co-analyzed. In combination with genomic surveillance, the clinical outcome-associated mutations could help identify individuals for priority medical support.

show abstract

Reinfection or reactivation: Genome‐based two distinct SNP profile of SARS‐CoV2 repositivity in an Indian case

Cited by 3 publications

References 12 publications

Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection Cases Corroborated by Sequencing

Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection Cases Corroborated by Sequencing

Reinfection in patients with COVID-19: a systematic review

Clinico-Genomic Analysis Reveals Mutations Associated with COVID-19 Disease Severity: Possible Modulation by RNA Structure

Contact Info

Product

Resources

About