Reinfection rate and endoscopic changes after successful eradication of<i>Helicobacter pylori</i>

Ryu, Kum Hei; Yi, Sun Young; Na, Youn Ju; Baik, Su Jung; Yoon, Seong Kuk; Jung, Hae Sun; Song, Hyun Joo

doi:10.3748/wjg.v16.i2.251

Cited by 18 publications

(15 citation statements)

References 22 publications

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“…The same study also reported that in areas of high prevalence of H. pylori, opportunities for horizontal transmission (from individuals outside the household) are higher. On the other hand, reinfection and recrudescence may occur after eradication therapy, supporting the acquisition of the bacteria during adulthood [33, 34]. …”

Section: Discussionmentioning

confidence: 99%

Epidemiology of Helicobacter pylori infection in six Latin American countries (SWOG Trial S0701)

Porras

Nodora

Sexton

et al. 2012

Cancer Causes Control

114

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Objective To investigate the potential determinants of Helicobacter pylori infection between adults 21–65 years old. Methods Data are from the initial screening visit of a randomized clinical trial of three antibiotic regimens to eradicate H. pylori, conducted in seven sites (Santiago–Chile, Túquerres–Colombia, Guanacaste–Costa Rica, Copán–Honduras, Obregón and Tapachula–México, León–Nicaragua). Thousand eight hundred and fifty-nine adults from the general population were screened for H. pylori infection using an urea breath test (UBT) and were interviewed to assess socioeconomic-, demographic-, and symptom-related characteristics. Logistic regression was used to assess the relationship between these characteristics and H. pylori positivity at enrollment. Results Among the 1,852 eligible participants for whom a conclusive UBT result was obtained, H. pylori prevalence was 79.4 %, ranging from 70.1 to 84.7 % among the seven centers. Prevalence did not differ by sex (female: 78.4, male: 80.9; p = 0.20) or age (p = 0.08). H. pylori positivity increased with increasing number of siblings (p trend <0.0001). Participants with education beyond 12 years were less likely to be UBT-positive (OR 0.4: 0.3–0.6, compared to participants with 0–6 years of schooling) as were those employed outside the home (OR 0.7: 0.6–1.0). Odds of H. pylori infection increased with the presence of certain living conditions during childhood including having lived in a household with an earth floor (OR 1.8: 1.4–2.4), lack of indoor plumbing (OR 1.3: 1.0–1.8) and crowding (OR 1.4: 1.0–1.8, for having more than two persons per bedroom). Regarding current household conditions, living with more than 3 children in the household (OR 1.7: 1.2–2.5) and crowding (OR 1.8: 1.3–2.3) were associated with H. pylori infection. Conclusions The prevalence of H. pylori in adults was high and differed significantly among the six Latin American countries studied (p < 0.001). Our findings confirm the strong link between poor socioeconomic conditions and H. pylori infection.

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Section: Discussionmentioning

confidence: 99%

Epidemiology of Helicobacter pylori infection in six Latin American countries (SWOG Trial S0701)

Porras

Nodora

Sexton

et al. 2012

Cancer Causes Control

114

View full text Add to dashboard Cite

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“…In fact, many studies document persistence of H. pylori infection in the follow-up of patients even after appropriate treatment [11][12][13][14][15][16]. In our clinical team, the antibiotic protocol evolved according to successive guidelines, and remained based on a combination of amoxicillin+clarithromycin or metronidazole+omeprazole.…”

Section: Persistence Of H Pylori Infection After An Initial Positivementioning

confidence: 99%

Follow-up ofHelicobacter pyloriinfection in children over two decades (1988–2007): persistence, relapse and acquisition rates

et al. 2013

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Helicobacter pylori culture on gastric biopsy was performed on 4964 subjects aged <18 years from 1988 to 2007 at a central laboratory in Brussels. The total number of biopsies increased markedly from 941 in 1988-1993 to 1608 in 2004-2007. Biopsies were repeated at least once for 922 subjects (603 initially negative and 319 initially positive for H. pylori). Persistence rate of H. pylori at 1 year after initial positive biopsy was greater in the 1998-2007 cohort than in the 1988-1997 cohort (72.7% vs. 45.8%, P = 0.002), suggesting a tailored selection of candidates for biopsy with non-invasive tests (13C urea breath test). Of 68 subjects initially positive and re-examined subsequently after a documented cure, re-infection/relapse rate was 48.6% within 5 years post-elimination of H. pylori. Acquisition rate over 10 years follow-up in the initially negative cohort (603 patients) was 38.7% (re-infection/relapse vs. acquisition: P < 0.001). Multivariate analysis showed a fourfold greater risk of H. pylori acquisition in children of non-European origin vs. European origin (P < 0.001). Clarithromycin and metronidazole susceptibility were determined in 226 and 223 paired positive cultures in cases of re-infection/relapse or persistence. An initial non-susceptibility profile was highly predictive of a subsequent non-susceptibility profile, and the non-susceptible proportion increased markedly from 13.3% to 21.2% for clarithromycin (P < 0.001) and from 27.3% to 35.0% for metronidazole (P = 0.014), with no difference regarding European or non-European origin.

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“…Compared with reinfection, the time window for recrudescence is generally shorter. Recrudescence is generally considered as H pylori recurrence within 1 year after eradication, followed by the recurrence of H pylori –associated diseases in the short‐term . Patients with short‐term recurrence suffer from the risk of recurrence of these diseases.…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori recrudescence and its influencing factors

Sun

Zhang

2019

J Cellular Molecular Medi

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Helicobacter pylori (H pylori) is known as one of the most common infectious pathogens, with high infection and recurrence rates worldwide. The prevalence of H pylori is up to 90% in developing countries, while the annual recurrence rate is much higher than that in developed countries. Recurrence can occur either by recrudescence or reinfection. Compared with reinfection, the time window for recrudescence is generally shorter, followed by the recurrence of H pylori–associated diseases in the short‐term. Many factors are involved in the H pylori reinfection, such as the prevalence of H pylori infection, living conditions and economic development, health conditions and so forth. Previous studies focused less on H pylori recrudescence. Therefore, the influencing factors for H pylori recrudescence needed further exploration. This study reviewed the recrudescence of H pylori infection and its influencing factors.

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Reinfection rate and endoscopic changes after successful eradication ofHelicobacter pylori

Abstract: The reinfection rate in Korea is 9.1% which represents a decreasing trend. There was no relationship between H. pylori infection status and changes in endoscopic findings. There was also no recurrence or aggravation of ulcers.

Cited by 18 publications

References 22 publications

Epidemiology of Helicobacter pylori infection in six Latin American countries (SWOG Trial S0701)

Epidemiology of Helicobacter pylori infection in six Latin American countries (SWOG Trial S0701)

Follow-up ofHelicobacter pyloriinfection in children over two decades (1988–2007): persistence, relapse and acquisition rates

Helicobacter pylori recrudescence and its influencing factors

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