Reinfection rate following effective therapy against <i>Helicobacter pylori</i> infection in Japan

Adachi, Masayasu; Mizuno, Motowo; Yokota, Kenji; Miyoshi, Masatsugu; Nagahara, Yasuhiro; Maga, Toshirou; Ishiki, Kuniharu; Inaba, Tomoki; Okada, Hiroyuki; Oguma, Keiji; Tsuji, Takao

doi:10.1046/j.1440-1746.2002.02666.x

Cited by 35 publications

(26 citation statements)

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“…Others [32] have reported a higher H. pylori reinfection rate in Japan (2.0% per year) than we have found previously [21] and in the present study. We cannot readily explain these differences.…”

Section: Discussionsupporting

confidence: 52%

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Reinfection rate of Helicobacter pylori after eradication treatment: a long-term prospective study in Japan

Take

Mizuno²,

Ishiki

et al. 2012

J Gastroenterol

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Section: Discussionsupporting

confidence: 52%

“…We previously reported that the reinfection rate with H. pylori in this population was low (\0.8% per patient year) despite the high prevalence of infection [21]. However, in that study, several factors could have led to misleading results.…”

Section: Introductionmentioning

confidence: 71%

Reinfection rate of Helicobacter pylori after eradication treatment: a long-term prospective study in Japan

Take

Mizuno²,

Ishiki

et al. 2012

J Gastroenterol

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“…Our PubMed search yielded 10 studies of H. pylori recurrence conducted in developed countries [4][5][6][7][8][9][10][11][12][13], and 7 studies conducted in developing countries [14 -20] that used the 13 CUBT at eradication and follow-up and otherwise met our inclusion criteria. Table 1 summarizes the studies from the developed countries, and Table 2, the studies from the developing countries.…”

Section: Resultsmentioning

confidence: 99%

“…3 for the developed countries [4,6,7,[10][11][12][13], and in Fig. 4 for the developing countries [16,17,19,20].…”

Section: Resultsmentioning

confidence: 99%

Helicobacter pylori Recurrence in Developed and Developing Countries: Meta‐Analysis of ¹³C‐Urea Breath Test Follow‐Up after Eradication

Niv

Hazazi

2008

Helicobacter

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Objective: Recurrence of Helicobacter pylori infection after eradication is rare in developed countries and more frequent in developing countries. Most recurrent cases are attributed to recrudescence (recolonization of the same strain within 12 months) rather than to reinfection (colonization with a new strain after more than 12 months). The aim of the study was to analyze recurrence rates in developed and developing countries and to deduce the relative roles of recrudescence and reinfection. Methods: The PubMed database was searched up to January 31, 2007 using the keywords " Helicobacter pylori " or " H. pylori " and "recurrence" or "recrudescence," or "reinfection." Only prospective case studies in adults that used the 13 C-urea breath test ( 13 CUBT) were included. Meta-analyses were performed with STATDIRECT Statistical software, version 2.6.1, StatsDirect Ltd, Chesire, UK. Results: The literature search yielded 10 studies of H. pylori recurrence in developed countries (3014 patients followed for 24-60 months) and 7 studies in developing countries (2071 patients followed for 12-60 months). The calculated annual recurrence rates were 2.67% and 13.00%, respectively. Nested metaanalysis of cases with a longer follow-up after eradication revealed an annual recurrence rate of 1.45% (RR 0.54) in developed countries and 12.00% (RR 0.92) in developing countries. Conclusions: The similarity of the annual recurrence rates during the first year after eradication and the annual recurrence rates in the second year after successful eradication in developing countries supports reinfection as the main cause in the second period. Therefore, a different approach for followup of H. pylori eradication may be needed between developed and developing countries. KeywordsHelicobacter pylori , eradication, recurrence, recrudescence, reinfection. Recurrence of Helicobacter pylori ( H. pylori ) infection after successful eradication is rare in developed countries and more frequent in developing countries [1]. Recrudescence (recolonization of the same strain) rather than reinfection (colonization with a new strain) is considered the more likely culprit in most cases [2]. However, this assumption is based on studies using heterogeneous testing methods and strategies, such as The aim of the present meta-analysis was to provide a more accurate assessment of H. pylori recurrence rates in developed and developing countries, and to deduce from these findings the relative roles of recrudescence and reinfection. To avoid the bias introduced by the different approaches used, we limited our database search to studies in adults in which the 13 CUBT was administered at completion of treatment, with a minimum follow-up of 12 months. We also performed a nested analysis of findings Reprint requests to

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“…We have reported results on several important medical issues in these patients [15][16][17][18][19][20][21][22]. Most importantly, the eradication of H. pylori in patients with peptic ulcer diseases in whom the cancer was not yet established reduced their risk of developing gastric cancer to approximately one-third.…”

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The long-term risk of gastric cancer after the successful eradication of Helicobacter pylori

Mizuno²,

et al. 2010

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Reinfection rate following effective therapy against Helicobacter pylori infection in Japan

Abstract: The reinfection rate after eradication of H. pylori is low in Japan despite the country's high prevalence of H. pylori infection.

Cited by 35 publications

References 22 publications

Reinfection rate of Helicobacter pylori after eradication treatment: a long-term prospective study in Japan

Reinfection rate of Helicobacter pylori after eradication treatment: a long-term prospective study in Japan

Helicobacter pylori Recurrence in Developed and Developing Countries: Meta‐Analysis of ¹³C‐Urea Breath Test Follow‐Up after Eradication

The long-term risk of gastric cancer after the successful eradication of Helicobacter pylori

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Reinfection rate following effective therapy against Helicobacter pylori infection in Japan

Abstract: The reinfection rate after eradication of H. pylori is low in Japan despite the country's high prevalence of H. pylori infection.

Cited by 35 publications

References 22 publications

Reinfection rate of Helicobacter pylori after eradication treatment: a long-term prospective study in Japan

Reinfection rate of Helicobacter pylori after eradication treatment: a long-term prospective study in Japan

Helicobacter pylori Recurrence in Developed and Developing Countries: Meta‐Analysis of 13C‐Urea Breath Test Follow‐Up after Eradication

The long-term risk of gastric cancer after the successful eradication of Helicobacter pylori

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Helicobacter pylori Recurrence in Developed and Developing Countries: Meta‐Analysis of ¹³C‐Urea Breath Test Follow‐Up after Eradication