Reinforced conductive polyester based on itaconic acids, glycerol and polypyrrole with potential for electroconductive tissue restoration

Ghaffari-Bohlouli, Pejman; Golbaten-Mofrad, Hooman; Najmoddin, Najmeh; Goodarzi, Vahabodin; Shavandi, Amin; Chen, Wei‐Hsin

doi:10.1016/j.synthmet.2022.117238

Cited by 11 publications

(4 citation statements)

References 62 publications

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“…In our previous work, PGIt was synthesized, and clay nanoparticles and polypyrrole (PPy) were added to induce speci c properties. Their results showed that this new structure has a very high capability in tissue engineering applications [25]. In this present research, PCL-diol was synthesized using the ring-opening polymerization method, and this material is used with two distinct purposes within PGIt.…”

Section: Introductionmentioning

confidence: 92%

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Synthesis and Characterization of Bio-nanocomposites Based on Poly(Glycerol Itaconic acid) (PGIt) and Using Poly(ɛ- caprolactone) diol (PCL-diol) as Macro Crosslinkers containing Cloisite Na + to application in Tissue engineering

Mahdavi

Zahedi

Goodarzi

2023

Preprint

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Biomaterials are a crucial issue in the field of tissue engineering. Two types of polymeric biomaterials, such as Poly(glycerol Itaconic acid) (PGIt) and Poly(ɛ-caprolactone) diol (PCL-diol), were synthesized by polycondensation and ring opening polymerization (ROP) respectively. The PCL-diol was selected as a minor phase with 30 and 50 wt.%, and Closite-Na+ was selected as the nanophase with a constant amount of 5 wt.%. Molecular structures PGIt and PCL-diol were analyzed by FTIR, 1H-NMR, and GPC techniques. Microstructures showing the presence of PCL-diol in the PGIt have not created compatible morphologies, albeit the presence of clay nanoparticles has helped to achieve the proper morphologies. Low angle XRD showed exfoliated, and intercalated morphologies can be predicted to pure PGIt and PGIt70PCLdiol30Clay5 samples. Mechanical analysis showed that Young’s modulus and elongation at the break of PGIt50PCLdiol50Clay5 and PGIt100 samples were higher than other samples. DMTA analysis showed that adding PCL-diol into the PGIt increased glass transition temperature (Tg) and storage modulus at 37oC. The master curve of the studied samples was prepared by the WLF equation at body temperature. Hydrocatalytical degradation, contact angles, and MTT analysis showed that all samples behave well in biological conditions. Cell adhesion, Dapi, and Alizarin red analysis were carried out on the selected samples, and their results showed that the presence of PCL-diol and Clay into the PGIt has improved the biological behavior of the sample and PGIt50PCLdiol50Clay5 shows just behavior.

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Section: Introductionmentioning

confidence: 92%

“…PGIt pre-polymer was synthesized following the procedure described in our previous papers [25]. Brie y, glycerol and itaconic Acid (I.A.)…”

Section: Synthesis Of Pgitmentioning

confidence: 99%

Synthesis and Characterization of Bio-nanocomposites Based on Poly(Glycerol Itaconic acid) (PGIt) and Using Poly(ɛ- caprolactone) diol (PCL-diol) as Macro Crosslinkers containing Cloisite Na + to application in Tissue engineering

Mahdavi

Zahedi

Goodarzi

2023

Preprint

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“…Synthetic biodegradable polyesters are a widely used type of polymer in tissue engineering due to their biodegradability and cost-effectiveness. Among them, aliphatic polyesters have been extensively investigated for their mechanical properties and ability to control biodegradation rates through chemical modifications [1][2][3][4][5][6][7][8]. However, creating a scaffold that mimics the extracellular matrix of the target tissue while maintaining appropriate mechanical properties, porosity, and biocompatibility remains challenging [9,10].…”

Section: Introductionmentioning

confidence: 99%

The Influence of the Molecular Weight of Poly(Ethylene Oxide) on the Hydrolytic Degradation and Physical Properties of Polycaprolactone Binary Blends

Dalton

Ebrahimi

et al. 2023

Macromol

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The use of biodegradable polymers in tissue engineering has been widely researched due to their ability to degrade and release their components in a controlled manner, allowing for the potential regeneration of tissues. Melt blending is a common method for controlling the degradation rate of these polymers, which involves combining these materials in a molten state to create a homogenous mixture with tailored properties. In this study, polycaprolactone (PCL) was melt blended with hydrophilic poly (ethylene oxide) (PEO) of different molecular weights to assess its effect on PCL material performance. Hydrolytic degradation, thermal and viscoelastic properties, and surface hydrophilicity were performed to contrast the properties of the blends. DSC, DMA, and FTIR were performed on selected degraded PCL/PEO specimens following mass loss studies. The results showed that adding PEO to PCL reduced its melt viscosity-torque and melt temperature while increasing its hydrophilicity, optimizing PCL/PEO blend for soft tissue engineering applications and could contribute to the development of more effective and biocompatible materials for soft tissue regeneration.

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“…PPy has saturated single σ-bonds and unsaturated double σ-bond and π-bond in its structure, enabling electric conductivity. Other unique characteristics of PPy include high biocompatibility and stability at room temperature, which can be easily synthesized (Ghaffari-Bohlouli et al, 2023;Qu et al, 2022). PPy is commonly used as a matrix for biorecognition element immobilization on a transducer; one such application is immunosensors (Kwon et al, 2019;Ramanaviciene & Ramanavicius, 2002).…”

Section: Conductive Polymers In Biosensingmentioning

confidence: 99%

Formation of metal-biomaterials nanocomposites and their application for the development of immunosensors

Zinovičius

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Disertacija rengta 2020-2024 metais Vilniaus Gedimino technikos universitete. Vadovė doc. dr. Inga MORKVĖNAITĖ-VILKONČIENĖ (Vilniaus Gedimino technikos universitetas, Medžiagų inžinerija -T 008). Vilniaus Gedimino technikos universiteto Medžiagų inžinerijos mokslo krypties disertacijos gynimo taryba: Pirmininkas doc. dr. Justinas GARGASAS (Vilniaus Gedimino technikos universitetas, Medžiagų inžinerija -T 008). Nariai: dr. Valentin ANTONOVIČ (Vilniaus Gedimino technikos universitetas, Medžiagų inžinerija -T 008), dr. Anna OSTASZEWSKA-LIŻEWSKA (Varšuvos technologijos universitetas, Lenkija, Mechanikos inžinerija -T 009), dr. Eugenijus VALATKA (Kauno technologijos universitetas, Chemija -N 003), doc. dr. Nikolaj VIŠNIAKOV (Vilniaus Gedimino technikos universitetas, Medžiagų inžinerija -T 008). Disertacija bus ginama viešame Medžiagų inžinerijos mokslo krypties disertacijos gynimo tarybos posėdyje 2024 m. birželio 6 d. 14 val. Vilniaus Gedimino technikos universiteto SRA-I posėdžių salėje.

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Reinforced conductive polyester based on itaconic acids, glycerol and polypyrrole with potential for electroconductive tissue restoration

Cited by 11 publications

References 62 publications

Synthesis and Characterization of Bio-nanocomposites Based on Poly(Glycerol Itaconic acid) (PGIt) and Using Poly(ɛ- caprolactone) diol (PCL-diol) as Macro Crosslinkers containing Cloisite Na + to application in Tissue engineering

Synthesis and Characterization of Bio-nanocomposites Based on Poly(Glycerol Itaconic acid) (PGIt) and Using Poly(ɛ- caprolactone) diol (PCL-diol) as Macro Crosslinkers containing Cloisite Na + to application in Tissue engineering

The Influence of the Molecular Weight of Poly(Ethylene Oxide) on the Hydrolytic Degradation and Physical Properties of Polycaprolactone Binary Blends

Formation of metal-biomaterials nanocomposites and their application for the development of immunosensors

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