Reinforced non-mulberry silk fibroin–fibroin nanocomposites and their optimization for tissue engineering applications

Baruah, Rashmi Rekha; Mohanta, Yugal Kishore; Saha, Muktashree; Ghosh, Siddhartha Sankar; Kalita, Mohan Chandra; Devi, Dipali

doi:10.1007/s10853-023-08625-x

Cited by 1 publication

(1 citation statement)

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“…The incorporation of SF with other materials such as graphene derivatives 21 , polymers 22 , 23 , and nanoparticles 24 can ameliorate its antimicrobial activity and develop new SF-based nanocomposites. On the other hand, a variety of structural forms of this biopolymer including gels, films, microsphere, and scaffolds have been well-investigated in drug delivery, tissue engineering, and other biomedical applications 17 , 25 . As developed in the last decades, the hyperthermia treatment has been emerged as a complementary modality to treat advanced cancer diseases and enhance the quality of a patient's life 26 , 27 .…”

Section: Introductionmentioning

confidence: 99%

Design and fabrication of a magnetic nanobiocomposite based on flaxseed mucilage hydrogel and silk fibroin for biomedical and in-vitro hyperthermia applications

Radinekiyan,

Eivazzadeh-Keihan,

Naimi-Jamal

et al. 2023

Sci Rep

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In this research work, a magnetic nanobiocomposite is designed and presented based on the extraction of flaxseed mucilage hydrogel, silk fibroin (SF), and Fe3O4 magnetic nanoparticles (Fe3O4 MNPs). The physiochemical features of magnetic flaxseed mucilage hydrogel/SF nanobiocomposite are evaluated by FT-IR, EDX, FE-SEM, TEM, XRD, VSM, and TG technical analyses. In addition to chemical characterization, given its natural-based composition, the in-vitro cytotoxicity and hemolysis assays are studied and the results are considerable. Following the use of highest concentration of magnetic flaxseed mucilage hydrogel/SF nanobiocomposite (1.75 mg/mL) and the cell viability percentage of two different cell lines including normal HEK293T cells (95.73%, 96.19%) and breast cancer BT549 cells (87.32%, 86.9%) in 2 and 3 days, it can be inferred that this magnetic nanobiocomposite is biocompatible with HEK293T cells and can inhibit the growth of BT549 cell lines. Besides, observing less than 5% of hemolytic effect can confirm its hemocompatibility. Furthermore, the high specific absorption rate value (107.8 W/g) at 200 kHz is generated by a determined concentration of this nanobiocomposite (1 mg/mL). According to these biological assays, this magnetic responsive cytocompatible composite can be contemplated as a high-potent substrate for further biomedical applications like magnetic hyperthermia treatment and tissue engineering.

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