Reinforcement of a new calcium phosphate cement with RGD-chitosan-fiber

Abstract

Calcium phosphate cement (CPC) has been widely used in orthopedic and dental applications. A critical limitation of CPC is low strength and high susceptibility to severe fracture. Surgeons can use it only to reconstruct non-stress bearing bone, raising the need for a tougher new generation of CPC. Fibers have been used as a reinforcement of CPC to improve the strength of a pure CPC scaffold. The RGD peptides (Arg-Gly-Asp) have been used to improve the biocompatibility of the scaffold, via physical adsorption. The purpose of this study was to develop a novel CPC scaffold reinforced by RGD peptide-bearing chitosan fibers (RGD-fiber-CPC). Our data showed that the RGD-fiber-CPC scaffold had an increased flexural strength, and stimulated new bone formation in an animal model. The RGD-fiber-CPC is a novel bone graft substitute in orthopedic surgery.

A novel strategy to enhance interfacial adhesion in fiber-reinforced calcium phosphate cement

“…Regarding the biological characterization of these materials, a previous study by Wu et al (Wu et al 2013) evaluated the effect of the addition of chitosan fibers in a CPC on osteoblast-like cells. No -16 -differences were observed between the pristine CPC and the FRCPC on cell adhesion, proliferation or viability (up to 14 days of cell culture).…”

Coatings as the useful drug delivery system for the prevention of implant-related infections

“…However, these FDA approved antibiotics eluting PMMA bone cements are more appropriate being used as a preventative measure than for the treatment because of their lack of effect on active IRIs due to limited and burst release of embedded antibiotics [57, 58]. Antibiotics release from PMMA cements is mainly due to the diffusion through surface roughness, superficial pores, and surface erosion [46, 58, 59]. The release characteristic of PMMA was typically performed as a biphasic phase which included a burst head of initial release and a continued tail of ineffective release for weeks or months.…”

“…The calcium phosphate materials are degradable and the end products are calcium and phosphate (Ca 2+ , PO 4 3− ) that are biocompatible, bioactive, and stimulate new bone growth [59–62]. The injectable CPCs are now commercial available that can be solidified after implantation.…”

Investigating the addition of collagen and its integrin binding sequence (RGD) to glass polyalkenoate: In terms of material and cellular properties to explore a more biocompatible method of root caries restoration

“…An appreciation however, of their molecular structure indicates this is possible. Others have demonstrated that RGD can promote adhesion and osteoblast activation in relation to a pure calcium phosphate cement (31). It is worth noting that in this application the biological scaffold Chitosan improved the calcium phosphate's properties by a fibre reinforcing mechanism (31).…”