Reinforcing effects of oral cocaine: contextual determinants

Jones, Hendrée E.; Garrett, Bridgette E.; Griffiths, Roland R.

doi:10.1007/s002130000626

Cited by 18 publications

(16 citation statements)

References 19 publications

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“…Participants self-administered more d-amphetamine when they received feedback that the drug enhanced their performance. Consistent with these data are findings demonstrating that behavioral demands influence the reinforcing effects of stimulants (Silverman et al 1994a, b;Jones et al 2001;Stoops et al 2005a, b). For instance, Silverman et al (1994a) reported that participants chose to self-administer triazolam, a sedative, before a relaxation activity but d-amphetamine before a vigilance activity.…”

Section: Introductionsupporting

confidence: 56%

“…Indeed, a growing body of literature shows that reinforcing effects of stimulants are sensitive to behavioral demands following drug administration (Silverman et al 1994a, b;Comer et al 1996;Jones et al 2001;Stoops et al 2005a, b). Jones et al (2001), for example, found that cocainerelated reinforcing effects were enhanced during a vigilance activity, but the drug was avoided (placebo chosen) during the relaxation condition. Similarly, the reinforcing effects of oral d-amphetamine are increased before a vigilance activity, while the reinforcing effects of the sedative triazolam are increased prior to engaging in relaxation (Silverman et al 1994a).…”

Section: Discussionmentioning

confidence: 97%

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Methamphetamine self-administration by humans subjected to abrupt shift and sleep schedule changes

et al. 2008

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Section: Introductionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 97%

Methamphetamine self-administration by humans subjected to abrupt shift and sleep schedule changes

et al. 2008

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“…It would be useful to ascertain whether the effects we observed are found when setting and topic are varied. A number of studies have demonstrated that the effects of stimulants can be modified by environmental contingencies (e.g., Silverman et al 1994;Comer et al 1996;Jones et al 2001;Stoops et al 2005a, b). For example, amphetamine, cocaine, and methylphenidate have been shown to function as reinforcers under conditions that required vigilance but not under relaxation conditions (Silverman et al 1994;Jones et al 2001;Stoops et al 2005a).…”

Section: Discussionmentioning

confidence: 98%

Amphetamine analogs methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) differentially affect speech

et al. 2009

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Methamphetamine improved verbal fluency and MDMA adversely affected fluency. This pattern of effects is consistent with the effects of these drugs on functioning in other cognitive domains. In general, methamphetamine effects on speech were inconsistent with effects popularly attributed to this drug, while MDMA-related effects were in agreement with some anecdotal reports and discordant with others.

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“…One potential drawback, however, associated with the performance-enhancing effects of intranasal methamphetamine is that this characteristic of the drug might actually contribute to or enhance its abuse liability. Findings from numerous studies demonstrate that the reinforcing effects of stimulants are increased when performance is perceived to be improved following drug administration (Silverman et al, 1994a, b;Comer et al, 1996;Jones et al, 2001;Stoops et al, 2005a, b).…”

Section: Discussionmentioning

confidence: 99%

Acute Physiological and Behavioral Effects of Intranasal Methamphetamine in Humans

Hart

Gunderson

Perez

et al. 2007

Neuropsychopharmacol

116

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Intranasal methamphetamine abuse has increased dramatically in the past decade, yet only one published study has investigated its acute effects under controlled laboratory conditions. Thus, the current study examined the effects of single-dose intranasal methamphetamine administration on a broad range of behavioral and physiological measures. Eleven nontreatment-seeking methamphetamine abusers (two females, nine males) completed this four-session, in-patient, within-participant, double-blind study. During each session, one of four intranasal methamphetamine doses (0, 12, 25, and 50 mg/70 kg) was administered and methamphetamine plasma concentrations, cardiovascular, subjective, and psychomotor/cognitive performance effects were assessed before drug administration and repeatedly thereafter. Following drug administration, methamphetamine plasma concentrations systematically increased for 4 h postdrug administration then declined. Methamphetamine dose dependently increased cardiovascular measures and 'positive' subjective effects, with peaks occurring approximately 5-15 min after drug administration, when plasma levels were still ascending. In addition, cognitive performance on less complicated tasks was improved by all active methamphetamine doses, whereas performance on more complicated tasks was improved only by the intermediate doses (12 and 25 mg). These results show that intranasal methamphetamine produced predictable effects on multiple behavioral and physiological measures before peak plasma levels were observed. Of interest is the dissociation between methamphetamine plasma concentrations with cardiovascular measures and positive subjective effects, which might have important implications for potential toxicity after repeated doses. INTRODUCTIONAlthough methamphetamine abuse has increased dramatically over the past decade, much of our knowledge about its acute effects in humans is anecdotal. The drug is frequently abused via the intranasal, i.v., and smoked routes (Domier et al, 2000; Community Epidemiology Work Group, 2005), but few studies have evaluated the acute effects of methamphetamine in humans using these routes of administration. The majority of studies conducted with humans have focused primarily on the cardiovascular and subjective effects produced by oral methamphetamine, a route of administration least often associated with abuse presumably due to its slow onset of effects. The onset of peak effects produced by oral methamphetamine does not occur until about 90 min after the administration (Hart et al, 2001a). By comparison, peak effects produced by intranasal, smoked, and i.v. methamphetamine occur within 15 min (Harris et al, 2003;Newton et al, 2005).Given that the rapidity of drug-related effects is a critical determinant of abuse liability (Hatsukami and Fischman, 1996), it is surprising that only a few studies have examined methamphetamine-related effects via routes of administration other than oral (eg Cook et al, 1993;Mendelson et al, 1995;Newton et al, 2006). Although inhalation by s...

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Reinforcing effects of oral cocaine: contextual determinants

Abstract: The study shows that the behavioral requirements following drug ingestion can be a determinant of whether or not oral cocaine functions as a reinforcer in volunteers with histories of cocaine abuse.

Cited by 18 publications

References 19 publications

Methamphetamine self-administration by humans subjected to abrupt shift and sleep schedule changes

Methamphetamine self-administration by humans subjected to abrupt shift and sleep schedule changes

Amphetamine analogs methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) differentially affect speech

Acute Physiological and Behavioral Effects of Intranasal Methamphetamine in Humans

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