Reinforcing involvement of NK cells in psoriasiform dermatitis animal model

Surcel, Mihaela; Munteanu, Adriana; Huică, Radu‐Ionuț; Isvoranu, Gheorghița; Pîrvu, Ioana Ruxandra; Constantin, Carolina; Bratu, Ovidiu Gabriel; Căruntu, Constantin; Zaharescu, Isadora; Sima, Lucica; Costache, Marieta; Neagu, Monica

doi:10.3892/etm.2019.7967

Cited by 9 publications

(7 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the imiquimod-induced psoriasis-like dermatitis mouse model, NK cells are decreased in the peripheral blood and spleen [108]. However, the role of NK cells in psoriasis mouse models remains unclear, although NK cell maturation markers, such as CD11b, CD43, CD27, and killer cell lectin-like receptor G1 (KLRG1), increase in peripheral blood and spleen NK cells from imiquimod-treated mice [109]. Furthermore, alterations in maturation marker expression are correlated with disease severity [109].…”

Section: Nk Cells In Mouse Models Of Psoriasismentioning

confidence: 99%

Role of Innate Immune Cells in Psoriasis

Sato

Ogawa

Okuyama

2020

IJMS

View full text Add to dashboard Cite

Psoriasis is a chronic inflammatory skin condition caused by a combination of hereditary and environmental factors. Its development is closely related to the adaptive immune response. T helper 17 cells are major IL-17-producing cells, a function that plays an important role in the pathogenesis of psoriasis. However, recent findings have demonstrated that innate immune cells also contribute to the development of psoriasis. Innate lymphoid cells, γδ T cells, natural killer T cells, and natural killer cells are activated in psoriasis, contributing to disease pathology through IL-17-dependent and -independent mechanisms. The present review provides an overview of recent findings, demonstrating a role for innate immunity in psoriasis.

show abstract

Section: Nk Cells In Mouse Models Of Psoriasismentioning

confidence: 99%

Role of Innate Immune Cells in Psoriasis

Sato

Ogawa

Okuyama

2020

IJMS

View full text Add to dashboard Cite

show abstract

“…For NK cells phenotypic characterization we used a large panel of surface markers including activation, maturation, and markers for cytokine receptors. The results showed important differences in IMQtreated mouse NK cell phenotype as compared to controls [83]. Taking into account the recently found relation between gut microbiota and Ps initiation, we have demonstrated that oral ingestion of IgY raised against pathological gut bacteria resistant to antibiotics can alleviate psoriatic lesions and restore immune parameters [18].…”

Section: Immune Cells Like Activated Dermal Dcs Can Circulate Through...mentioning

confidence: 84%

Immune Markers in Psoriasis

Surcel¹,

Munteanu²,

Constantin³

et al. 2022

Psoriasis - New Research

Self Cite

View full text Add to dashboard Cite

Psoriasis is a chronic inflammatory skin disorder with high immunological background caused by a complex interplay between an altered immune system, genetic factors, autoantigens, lifestyle, and environmental factors. Extensive literature in recent years highlighted the crucial role played by the immune system in the pathogenesis of this pathology. Although it is unequivocally accepted that psoriasis is a T-cell mediated autoimmune condition, both innate and specific immune cells are highly involved in the pathogenesis of psoriasis. The aberrant interactions between immune cells and resident hyper-proliferative keratinocytes are mediated by immune and non-immune related molecules which lead to amplification of the local immune responses, that maintain the chronic inflammatory status. In this chapter, we will highlight the immune molecules resident in the psoriatic tissue or appending to the blood circulation that can indicate the prognosis of this systemic autoimmune disease. Moreover, we will focus on immune cells resident or circulating ones that can pinpoint the clinical evolution of the psoriatic disease. All these data can be developed in immune markers patterns that aid psoriasis diagnosis and/or future (immune)therapies.

show abstract

“…IgY was isolated from the yolk of hyperimmune eggs laid by chickens immunized with human pathogenic bacteria that are antibiotic-resistant, namely groups of pathogens with a high rate of antibiotic resistance responsible for the majority of nosocomial infections. IgY was obtained according to the methodology described in the patent [ 45 ]. The obtained IgY is an original product of the ROMVAC Company and is part of the IMUNOINSTANT brand having a European trademark (EUIPO).…”

Section: Methodsmentioning

confidence: 99%

“…The mice were monitored daily. The experiments were conducted in accordance with recognized principles of laboratory animal care in the framework of EU Directive 2010/63/EU [ 45 ] and the study was comprised in a research project that was approved by the Ethics Committee from Victor Babeș Institute (Approval no 88/20 January 2021) and National Sanitary Veterinary and Food Safety Authority (Approval no 598/8 February 2021).…”

Section: Methodsmentioning

confidence: 99%

Unconventional Therapy with IgY in a Psoriatic Mouse Model Targeting Gut Microbiome

Surcel

Munteanu

Isvoranu

et al. 2021

JPM

Self Cite

View full text Add to dashboard Cite

Psoriasis has a multifactorial pathogenesis and recently it was shown that alterations in the skin and intestinal microbiome are involved in the pathogenesis of psoriasis. Therefore, microbiome restoration becomes a promising preventive/therapy strategy in psoriasis. In our pre-clinical study design using a mice model of induced psoriatic dermatitis (Ps) we have tested the proof-of-concept that IgY raised against pathological human bacteria resistant to antibiotics can alleviate psoriatic lesions and restore deregulated immune cell parameters. Besides clinical evaluation of the mice and histology of the developed psoriatic lesions, cellular immune parameters were monitored. Immune cells populations/subpopulations from peripheral blood and spleen cell suspensions that follow the clinical improvement were assessed using flow cytometry. We have quantified T lymphocytes (CD3ε+) with T-helper (CD4+CD8−) and T-suppressor/cytotoxic (CD8a+CD4−) subsets, B lymphocytes (CD3ε−CD19+) and NK cells (CD3ε−NK1.1+). Improved clinical evolution of the induced Ps along with the restoration of immune cells parameters were obtained when orally IgY was administered. We pin-point that IgY specific compound can be used as a possible pre-biotic-like alternative adjuvant in psoriasis.

show abstract

Reinforcing involvement of NK cells in psoriasiform dermatitis animal model

Cited by 9 publications

References 49 publications

Role of Innate Immune Cells in Psoriasis

Role of Innate Immune Cells in Psoriasis

Immune Markers in Psoriasis

Unconventional Therapy with IgY in a Psoriatic Mouse Model Targeting Gut Microbiome

Contact Info

Product

Resources

About