Reinforcing properties of the neuropeptide substance P in Carassius auratus: Evidence of dopaminergic system involvement

Can fish suffer?: perspectives on sentience, pain, fear and stress

“…Since administration of dopaminergic agonists (e.g. amphetamine, apomorphine) produces reward behaviour in both mammals and fish, it has been hypothesised that central reward mechanisms of fish are similar to those found in other vertebrates (Lett and Grant, 1989;Mattioli et al, 1995). This hypothesis is further supported by pharmacological studies investigating the effects of substance P on vertebrate behaviour.…”

“…This hypothesis is further supported by pharmacological studies investigating the effects of substance P on vertebrate behaviour. In addition to pain mediation, the neuropeptide substance P is involved in learning, memory and reward processes in mammals, and its effects may be mediated through dopaminergic systems (Mattioli et al, 1995). In fish, as in mammals, dopaminergic cell bodies can be located at similar brain regions where substance P terminals are found (Mattioli et al, 1997).…”

ACTH4 ‐10, Substance P, and Dizolcipine (Mk‐801) Accelerate Functional Recovery After Hemilabyrinthectomy in Goldfish

“…Both SP and ACTH have been shown to promote learning and memory (Greven & de Wied, 1973;de Wied & Gispen, 1977;Stiubli & Huston, 1980;Wetzel & Matthies, 1982;Tomaz & Huston, 1986;Tomaz et al, 1990;Wan et al, 1992;Huston & Hasen6hrl, 1995;Mattioli et al, 1997), and to have reinforcing effects in rats and goldfish (Huston & Oitzl, 1989;Oitzl et al, 1990;Huston & Hasen6hrl, 1995;Mattioli et al, 1995;, and such effects may facilitate functional recovery, for example, by improving behavioral compensation and re-learning. Effects on learning might also explain why the peptides acted rather rapidly and why their effectiveness outlasted drug discontinuation.…”

“…The final doses used were 50 Mg/kg for SP, 250 gg/kg for ACTH4-10, and 100 lag/kg for MK-801. These doses were derived from previous studies (Flohr & Liineburg, 1982;Mattioli et al, 1995Mattioli et al, , 19961997) (Ott & Platt, 1988a, 1988b …”

Bienestar en peces y aspectos reglamentarios en Colombia para la explotación de especies ícticas con fines experimentales y comerciales

“…En este sentido, varios autores afirman que la ablación del telencéfalo en la especie Caracius auratus afecta el aprendizaje asociativo, de manera similar a las lesiones del hipocampo en mamíferos y aves (López, Broglio, Rodríguez, Thinus & Salas, 2000;vargas, Rodríguez, López, Arias & Salas, 2000); además, tanto en otros vertebrados como en peces, similitudes relacionadas con el comportamiento social y sexual como respuesta a señales internas y ambientales se originan en áreas del telencéfalo relacionadas con el aprendizaje emocional (Portavella, vargas, Torres & Salas, 2002). Por otro lado, estudios sobre el sistema dopaminérgico y trabajos relacionados con estados como miedo, ansiedad y dolor, mediados a través de respuestas bioquímicas y comportamentales, han arrojado bases que concluyen similitud de respuestas en los peces estudiados, con otros vertebrados (Mattioli, Aguilar & vasconcelos, 1995;Sneddon, 2003;ullström, Parker, Svensson & Grillner, 1999;Castro, Becerra, Anadón & Manson, 2001;Eaton, Lee & Foreman, 2001). …”