Reinvestigation of Disulfiram-Like Biological Activity of Coprinus atramentarius (Bull. ex Fr.) Fr. Extracts

Poisoning by Coprinus atramentarius

“…Later, Vanhaelen et al [1976] isolated a biologically active compound which sensitized mice to alcohol, its chemical properties resembling those of oligopeptides, aminoacids, or amines like tryptamine. These additional data, although incomplete, reinforced the preceding results.…”

“…In 1975, Lindberg et al, in Sweden, and Hatfield and Schaumberg, in the United States, published almost simultaneously the isolation and the chemical structure of the active principle-coprine-pointing out that this compound was not active in vitro, hence suggesting that the effector is not coprine itself but rather a metabolite. Later, Vanhaelen et al [1976] isolated a biologically active compound which sensitized mice to alcohol, its chemical properties resembling those of oligopeptides, aminoacids, or amines like tryptamine. These additional data, although incomplete, reinforced the preceding results.…”