Reinvestigation of Passerini and Ugi scaffolds as multistep apoptotic inducers via dual modulation of caspase 3/7 and P53-MDM2 signaling for halting breast cancer

Abstract

Passerini and Ugi scaffolds as selective induction of breast cancer apoptosis are viewed as the mainstay of various ongoing oncology drug discovery programs.

Synthesis and Mechanism of p53‐MDM2 Inhibitors with Heterocyclic Structures: A Focused Review

“…P53 is a tumor suppressor gene, which can regulate the cell cycle and prevent cell carcinogenesis. [1][2][3] Mutation of p53 gene will cause the cell to lose the function of inhibiting cell carcinogenesis, so mutation of p53 gene is one of the important causes of tumor. p53-MDM2 inhibitors can inhibit p53-dependent gene transcription activity, inhibit p53-mediated apoptosis, block the cell cycle, and significantly reduce DNA formation, thereby achieving the purpose of treating cancer.…”

“…P53 is a tumor suppressor gene, which can regulate the cell cycle and prevent cell carcinogenesis [1–3] . Mutation of p53 gene will cause the cell to lose the function of inhibiting cell carcinogenesis, so mutation of p53 gene is one of the important causes of tumor.…”