Reirradiation for recurrent nasopharyngeal carcinoma: Factors affecting the therapeutic ratio and ways for improvement

Re-Treatment After Full-Course Radiotherapy: Is It a Viable Option?

“…Mazeron et al (58) report on a series of 70 patients re-treated between 1971 and 1980 for recurrent or new primary oropharyngeal cancer in previously irradiated sites. The total doses delivered by iridium implants were 50− 71 Gy in 4 to 7 days (mean 60 Gy).…”

Reirradiation with Robotic Stereotactic Body Radiotherapy for Recurrent Nasopharyngeal Carcinoma

“…In the reported reirradiation studies except those with BT alone, the majority of the recurrences are at advanced stage with a ratio of 15-73.3% and 8-53% for rT3-4 tumor and rStage-4 diseases, respectively (Lee et al, 1997;Xiao et al, 2001;Lu et al, 2004;Chua et al, 2005;Wu et al, 2007;Seo et al, 2009;Koutcher et al, 2010;Ozyigit et al, 2011). In our series the 41.7% of the cases were with rT3-4 and 29.2% were with rStage-4 disease.…”

“…Higher reirradiation dose (≥60 Gy) was associated with better survival outcome in some series (Wang, 1987;Pryzant et al, 1992;Lee et al, 1997;Teo et al, 1998). Chang et al (2000) reported improved survival with ≥50Gy.…”

Beating 'Guangdong cancer': a review and update on nasopharyngeal cancer

“…[45][46][47] With its introduction, IMRT has quickly emerged as the radiation modality of choice for rNPC as well, with or without the use of chemotherapy. Its efficacy has been established in various studies, with documented long-term OS rates ranging from 45% to 65%.…”