Reirradiation of primary brain tumours: survival, clinical response and prognostic factors

Veninga, Theo; Langendijk, Johannes A.; Slotman, Ben J.; Rutten, E.H.J.M.; Kogel, Albert J. van der; Prick, M. J. J.; Keyser, A.; Maazen, R.W.M. van der

doi:10.1016/s0167-8140(01)00299-7

Cited by 102 publications

(67 citation statements)

References 40 publications

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“…In this regard, several different modalities of percutaneous radiotherapy or brachytherapy for retreatment of glioblastomas have been investigated. In general, all data consistently show that, whenever employed cautiously, reirradiation is feasible and most likely prolongs survival [1,4,7,8,11,13,14,21,24,34,35,38,[40][41][42].…”

Section: Introductionmentioning

confidence: 76%

Hypofractionated reirradiation for recurrent malignant glioma

Henke

Paulsen²,

Steinbach

et al. 2009

Strahlenther Onkol

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Section: Introductionmentioning

confidence: 76%

Hypofractionated reirradiation for recurrent malignant glioma

Henke

Paulsen²,

Steinbach

et al. 2009

Strahlenther Onkol

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“…MALIGNANT GLIOMAS are one of the most radioresistant human tumors (1). Several clinical studies have determined that there is an association between oxygenation (tissue levels of oxygen either directly measured or inferred) and outcome from radiation therapy in certain human tumors (2)(3)(4).…”

mentioning

confidence: 99%

Changes in oxygenation of intracranial tumors with carbogen: A BOLD MRI and EPR oximetry study

Dunn

O’Hara

Wadghiri

et al. 2002

Magnetic Resonance Imaging

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Purpose: To examine, using blood oxygen level dependent (BOLD) MRI and EPR oximetry, the changes in oxygenation of intracranial tumors induced by carbogen breathing. Materials and Methods:The 9L and CNS-1 intracranial rat tumor models were imaged at 7T, before and during carbogen breathing, using a multi-echo gradient-echo (GE) sequence to map R 2 *. On a different group of 9L tumors, tissue pO 2 was measured using EPR oximetry with lithium phthalocyanine as the oxygen-sensitive material. Results:The average decline in R 2 * with carbogen breathing was 13 Ϯ 1 s -1 in the CNS-1 tumors and 29 Ϯ 4 s -1 in the 9L tumor. The SI vs. TE decay curves indicate the presence of multiple components in the tumor. Tissue pO 2 in the two 9L tumors measured was 8.6 Ϯ 0.5 and 3.6 Ϯ 0.6 mmHg during air breathing, and rose to 20 Ϯ 7 and 16 Ϯ 4 mmHg (mean Ϯ SE) with carbogen breathing. Significant changes were observed by 10 minutes, but changes in pO 2 and R 2 * continued in some subjects over the entire 40 minutes. Conclusion:EPR results indicate that glial sarcomas may be radiobiologically hypoxic. Both EPR and BOLD data indicate that carbogen breathing increases brain tumor oxygenation. These data support the use of BOLD imaging to monitor changes in oxygenation in brain tumors.

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“…Median OS from the time of reirradiation of 11 months in the current study were consistent with these outcomes. Suggested prognostic factors associated with improvement in OS were younger age, 12,18 higher KPS, 12,15,19,20 lower histologic grade at initial diagnosis, 12,23 lower histologic grade at recurrence, 15 longer interval between prior RT and reirradiation, 15,19 higher dose of re-irradiation, 12 smaller tumor volume at re-irradiation, 12,13,18 and MGMT methylation status. 19 In our single-institution patient series, KPS, dose of re-irradiation, and length of time between RT were significant potential prognostic factors influencing OS.…”

Section: Discussionmentioning

confidence: 99%