Rejuvenation Effects of Cataract Surgery with Ultraviolet Blocking Intra-Ocular Lens on Circadian Rhythm and Gait Speed

Abstract

Background: Previously, we reported improvements in sleep quality and gait speed after implantation of a yellow-colored, blue light-blocking intra-ocular lens (IOL). This study evaluated systemic health parameters for 7 months after cataract surgery with implantation of a clear, ultraviolet (UV)-blocking IOL. Methods: A total of consecutive 71 patients (average age 74.1 years) underwent cataract surgery with the implantation of a clear, UV-blocking IOL. Participants were evaluated using the Pittsburgh Sleep Quality Index (PSQI) and the National Eye Institute Visual Function Questionnaire (VFQ-25) before and at 2 and 7 months after surgery. Four-meter gait speed was also determined. The metabolic parameters of serum glycated hemoglobin (HbA1c), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were tested. Results: The pre-operative and post-operative (2 and 7 months after surgery) results were 66.4 -16.5, 79.5 -12.6, and 81.0 -13.0 for VFQ-25 score, 5.7 -3.5, 5.1 -3.1, and 4.8 -2.9 for PSQI, and 0.90 -0.22, 0.91 -0.22, and 0.92 -0.22 meters/sec for gait speed. Significant improvements following surgery were noted in the VFQ-25 score for all cases and in the PSQI for poor sleepers (preoperative PSQI > 5.5) (P < 0.05, paired t-test). The gait speed and metabolic parameters showed no significant changes. Conclusions: Cataract surgery with implantation of an UV-blocking clear IOL has the potential for improving circadian rhythm and systemic health parameters.

The effect of blue‐blocking and neutral intraocular lenses on circadian photoentrainment and sleep one year after cataract surgery

“…Sleep efficiency increased significantly exclusively for participants allocated to blue-blocking IOLs and WASO decreased (improved) for the entire population. This is in concordance with previous questionnaire-based studies (Ayaki et al 2013(Ayaki et al , 2014Wei et al 2013;Schmoll et al 2014) and on meta-analysis (ref review). However, another study also relying on actigraphy found no effect cataract surgery (Tanaka et al 2010).…”

“…This is in concordance with previous questionnaire-based studies (Ayaki et al 2013(Ayaki et al , 2014Wei et al 2013;Schmoll et al 2014) and on meta-analysis (ref review). Sleep efficiency increased significantly exclusively for participants allocated to blue-blocking IOLs and WASO decreased (improved) for the entire population.…”

“…Cataract surgery has been shown to improve subjective sleep quality (Asplund & Lindblad 2004;Ayaki et al 2013Ayaki et al , 2014 and cataract and increased lens yellowing have been associated with sleep disturbances (Kessel et al 2011;Kim et al 2012). This has led to the hypothesis that cataract may interfere with circadian photoentrainment by absorbing blue light essential to intrinsic activation of the intrinsically photosensitive retinal ganglion cells (ipRGCs) vital to circadian photoentrainment (Charman 2003).…”

Is Low Hemoglobin Concentration Highly Associated with the Onset of Cognitive Impairment in Elderly People?

“…2,3 Accumulating evidence suggests that sufficient oxygen for brain tissues may benefit a lot to the neurological and psychiatric symptoms. 4 This is only a necessary condition, rather than a decisive one.…”

Wirkung der Farbtemperatur des Lichts auf Konzentration und Kreativität

“…Auf diesen Effekt können auch Schlafstörungen im Alter zurückgeführt werden [38]. Bei Ersatz durch eine Acryllinse kann der zirkadiane Rhythmus verbessert werden [39,40]. Insbesondere der UV-Anteil des Lichts bzw.…”