reKinetics and Mass Transfer in the Hydrogenation of 2-((1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)methylene)-5,6-dimethoxy- -2,3-dihydroinden-1-one hydrochloride over Pt/C Catalyst

Abstract

The liquid phase hydrogenation of 2-((1-benzyl-1,2,3,6-tetrahydropyridin-4-yl) methylene)-5,6-dimethoxy-2,3-dihydroinden-1-one hydrochloride (1) over a 5 % Pt/C industrial catalyst was studied experimentally in a batch slurry reactor using methanol as a solvent. The catalyst was characterized by the adsorption techniques for specific surface area and pore volume, and by XRD for crystallinity. To investigate the intrinsic kinetics of the reaction, the effect of temperature, catalyst loading, hydrogen partial pressure and (1) concentration on the initial rate of hydrogenation was studied. The analysis of initial rate data showed that the gas-liquid, liquid-solid, and intraparticle mass-transfer resistances were not significant. The reaction scheme of (1) hydrogenation was proposed for the kinetic modelling. Apparent rate constants for all hydrogenation steps were calculated using a first order kinetic approach resulting in good agreement between the experimentally obtained and predicted concentrations. From the temperature dependence of rate constants, the activation energies of various reaction steps were calculated. The averaged activation energy of these steps was found to be 31.1 kJ mol -1 .

Catalytic Hydrogenation of 2-((1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydroinden-1-one Hydrochloride: Fractal-like and Weibull Model Kinetics

“…4 An experimentally based simple reaction scheme given in Figure 1 was derived for the hydrogenation of 1 to 2, with high selectivity of compound 2 formation. 5,6 The liquid-phase hydrogenation of 1 over heterogeneous 5% Pt/C catalyst is conducted in a rotary agitated batch reactor. Liquid− solid, gas−liquid, and intraparticle diffusion resistances are expected for solid−liquid−gas flows in the impeller agitated vessel.…”

“…Recently, the authors presented a detailed study of the search for a Pt/C catalyst that would meet requirements for high reaction selectivity, high activity, good stability, and prospect of the catalyst’s reuse . An experimentally based simple reaction scheme given in Figure was derived for the hydrogenation of 1 to 2 , with high selectivity of compound 2 formation. , The liquid-phase hydrogenation of 1 over heterogeneous 5% Pt/C catalyst is conducted in a rotary agitated batch reactor. Liquid–solid, gas–liquid, and intraparticle diffusion resistances are expected for solid–liquid–gas flows in the impeller agitated vessel.…”