Rekonstruktion des Steigbügeloberbaus beim Meerschweinchen mit einer Biovitrokeramik und Silikonfolie

Dost, Philip; Ellermann, Stefanie; Missfeldt, N; Jahnke, K.

doi:10.1007/s00106-002-0641-9

Cited by 8 publications

(7 citation statements)

References 7 publications

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“…However, only one research group has dealt with a middle ear model of mice for ossicular chain replacements so far [20][21][22]. Dost et al found new bone formation surrounding Bioverit Õ I þ II, hydroxyapatite and Ceravital Õ implants, and also in contact with the middle ear wall in guinea pigs [18,19,23]. Additionally, a significant amount of new bone around the ossicle was observed in a reconstruction with hydroxyapatite cement and dahllite cement [24].…”

Section: Animal Modelmentioning

confidence: 99%

Free Bioverit ^® II Implants Coated with a Nanoporous Silica Layer in a Mouse Ear Model — A Histological Study

et al. 2008

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The objective of this study is to evaluate the suitability of a mouse middle ear model for testing ossicular replacement materials. Twenty-four BALB/c mice are implanted with the bioglass-ceramic Bioverit Õ II which is coated with a silica-nanostructure or with plain Bioverit Õ II as a control. After 2, 6, and 12 weeks, 4 mice per group are sacrificed and both complete petrous bones are analyzed histologically. All implants revealed in situ an incipient growth of thin connective tissue layers over the surface, followed by a *Author to whom correspondence should be addressed. E-mail: Brandes.gudrun@mh-hannover.de spreading of epithelial cells. The osseogenic response which is increasing with time is more intense in the coated Bioverit Õ II specimens. The absence of inflammatory cells suggests an excellent biocompatibility of the silica nano structure. As the results are comparable to a study with the same materials in rabbits, the mouse model described is highly suitable for evaluation of new ossicular replacement materials. Additionally, by gene expression analysis a more detailed insight into cellular interactions of the middle ear is offered.

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Section: Animal Modelmentioning

confidence: 99%

Free Bioverit ^® II Implants Coated with a Nanoporous Silica Layer in a Mouse Ear Model — A Histological Study

et al. 2008

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“…Wie auch bei Glaskeramiken findet die Bindung zwischen der Oberfläche und benachbarten Weichteilen über die Ausbildung von Kollagenfasern statt [37] und führt dort zur Osteoneogenese. Dost und Mitarbeiter konnten im Tierversuch auch im Mittelohr bei Verwendung biaoaktiver Ossikelprothesen aus Hydroxylapatit, Glaskeramik (Ceravital ) oder Biovitrokeramik (Bioverit II ) eine Osteoneogenese demonstrieren [47]. Die osteogenetische Potenz des Apatits (BoneSource ) ist im Kulturmodell allerdings niedriger als die von Ethisorb [19].…”

Section: Titannetzeunclassified

Biomaterialien in der Schädelbasischirurgie

Maier¹

2009

Laryngo-Rhino-Otol

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Reconstruction materials and techniques for the skull base have undergone rapid developments and differentiation in recent years. While mostly autotransplants, collagens or resorbable alloplastic materials are preferred for duraplasties, pronounced organ-specific differences can be observed IN the reconstruction of hard tissues. The use of polymethylmethacryl bone cement, once wide-spread, has decreased greatly due to the release of toxic monomers. Bony autotransplants are still used primarily for smaller skull-base defects, intraoperatively formable titanium meshes may be also used for larger fronto- or laterobasal reconstructions of bony defects. Defects in visible areas are increasingly closed with preformed titanium or ceramic implants, which are planned and fitted to the individual patient using preoperative CT imaging. At the skull base, this applies especially to reconstructions of the frontal sinus. For extensive reconstructions of the orbita, titanium meshes and non-resorbable plastics have proven valuable, in closing smaller defects especially of the orbital floor, resorbable implants based on Polyglactin 901 are also used.

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“…As with glass ceramics, binding between the surface and neighboring soft tissue occurs via the formation of collagen fibers [37] and leads there to osteoneogenesis. In an animal experiment, Dost and his colleagues demonstrated osteoneogenesis in the middle ear, using bioactive ossicle prostheses made of hydroxylapatit, glass ceramic (Ceravital ® ), or biovitroceramic (Bioverit II ® ) [47]. The osteogenetic potency of apatit (BoneSource ® ) is, however, lower than that of Ethisorb ® in the culture model [19].…”

Section: Hard Tissue Replacementmentioning

confidence: 99%

Biomaterials in skull base surgery

Maier

2009

GMS Current Topics in Otorhinolaryngology - Head and Neck Surgery; 8:Doc07; ISSN 1865-1011

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Rekonstruktion des Steigbügeloberbaus beim Meerschweinchen mit einer Biovitrokeramik und Silikonfolie

Abstract: The guinea pig was not an ideal model for questions of middle ear reconstructions due to its enormous potential for bone formation. In this animal model bony fixation of glass-ceramic with the stapes-footplate could be induced.

Cited by 8 publications

References 7 publications

Free Bioverit ^® II Implants Coated with a Nanoporous Silica Layer in a Mouse Ear Model — A Histological Study

Free Bioverit ^® II Implants Coated with a Nanoporous Silica Layer in a Mouse Ear Model — A Histological Study

Biomaterialien in der Schädelbasischirurgie

Biomaterials in skull base surgery

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Rekonstruktion des Steigbügeloberbaus beim Meerschweinchen mit einer Biovitrokeramik und Silikonfolie

Abstract: The guinea pig was not an ideal model for questions of middle ear reconstructions due to its enormous potential for bone formation. In this animal model bony fixation of glass-ceramic with the stapes-footplate could be induced.

Cited by 8 publications

References 7 publications

Free Bioverit ® II Implants Coated with a Nanoporous Silica Layer in a Mouse Ear Model — A Histological Study

Free Bioverit ® II Implants Coated with a Nanoporous Silica Layer in a Mouse Ear Model — A Histological Study

Biomaterialien in der Schädelbasischirurgie

Biomaterials in skull base surgery

Contact Info

Product

Resources

About

Free Bioverit ^® II Implants Coated with a Nanoporous Silica Layer in a Mouse Ear Model — A Histological Study

Free Bioverit ^® II Implants Coated with a Nanoporous Silica Layer in a Mouse Ear Model — A Histological Study