2009
DOI: 10.1038/ng.395
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REL, encoding a member of the NF-κB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis

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Cited by 303 publications
(266 citation statements)
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“…In a recent study of RA risk (Stahl et al 2010), six genome-wide association studies totaling over 5500 cases and over 20,000 controls were combined through meta-analysis. These studies included a new GWAS dataset of cases from the Brigham Rheumatoid Arthritis Sequential Study ) and shared controls genotyped on the Affymetrix SNPChip 6.0 platform, three datasets genotyped on the Illumina HumanHap 317K and 550K platforms Remmers et al 2007;Gregersen et al 2009), and the Wellcome Trust Case Control Consortium (2007) data including nonautoimmune disease cases as shared controls, genotyped on the Affymetrix 500K platform. All samples were of selfdescribed European ancestry, with one sample set originating from Sweden, one from the United Kingdom, and four from North America.…”
Section: Meta-analysis Of Six Genome-wide Association Studies Identifmentioning
confidence: 99%
“…In a recent study of RA risk (Stahl et al 2010), six genome-wide association studies totaling over 5500 cases and over 20,000 controls were combined through meta-analysis. These studies included a new GWAS dataset of cases from the Brigham Rheumatoid Arthritis Sequential Study ) and shared controls genotyped on the Affymetrix SNPChip 6.0 platform, three datasets genotyped on the Illumina HumanHap 317K and 550K platforms Remmers et al 2007;Gregersen et al 2009), and the Wellcome Trust Case Control Consortium (2007) data including nonautoimmune disease cases as shared controls, genotyped on the Affymetrix 500K platform. All samples were of selfdescribed European ancestry, with one sample set originating from Sweden, one from the United Kingdom, and four from North America.…”
Section: Meta-analysis Of Six Genome-wide Association Studies Identifmentioning
confidence: 99%
“…The REL subunit has recently been identified in genomewide association studies as a genetic risk factor for RA (8). However, few in vivo studies have examined individual Rel/NF-kB subunits in relevant experimental models of inflammatory disease.…”
mentioning
confidence: 99%
“…BLK is one of the strongest risk genes for rheumatoid arthritis and systemic lupus erythematosus and CCL4 encodes a chemokine ligand involved in immune activation. [22][23][24][25][26] However, the connection between BLK and CCL4 remains speculative, as it is unclear whether the close proximity of the trans-SNP to CCL4 reflects a gene-or pathway-mediated mechanism, or whether other interaction mechanisms that do not involve CCL4 exist. Unfortunately, we could not test the effect of the trans-SNP on the expression of CCL4 because no probe for CCL4 has been included in our analysis.…”
Section: Resultsmentioning
confidence: 99%