Relação entre depressão, nível de BNP e comprometimento ventricular na insuficiência cardíaca

Aguiar, Vera Barretto; Ochiai, Marcelo Eidi; Cardoso, Juliano; Carlo, Carlos Henrique Del; Morgado, Paulo; Munhoz, Robinson Tadeu; Pereira-Barretto, Antônio Carlos

doi:10.1590/s0066-782x2010005000125

Cited by 10 publications

(6 citation statements)

References 23 publications

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“…Similar to the findings of our study, significantly lower BDNF levels are observed in patients with major depressive disorder compared to the control group 35. In contrast to our findings, in patients with heart failure, BDNF levels were reported to be higher in depressive patients compared to the patients without depression 36–38…”

Section: Discussionsupporting

confidence: 88%

Can low brain-derived neurotrophic factor levels be a marker of the presence of depression in obese women?

Güzel¹,

Bakkal²,

Güzel³

et al. 2014

NDT

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ObjectiveDepression is a common condition in obese women that can result in severe impairment of their physical and social functioning. A deficiency of brain-derived neurotrophic factor (BDNF) is involved in the mechanism of depression. The aim of this study is to investigate whether BDNF levels differ between obese female patients and healthy controls and whether BDNF levels alter with affective states in depressive obese women.MethodsThe study group included 40 obese, 40 preobese, and 40 normal weight women. BDNF levels were measured with an enzyme-linked immunosorbent assay in patient and control groups. For identifying the depression and anxiety status, Beck Depression/Anxiety Inventories were used; and for the evaluation of cognitive functions, the mini-mental state examination was used.ResultsBDNF levels were significantly lower in obese patients compared to the control group (P<0.01). BDNF levels were significantly lower in obese patients with depression compared to the obese patients without depression (P<0.05). The Beck Depression Inventory showed a negative correlation with BDNF (r=−0.044; P<0.01) and a positive correlation with the Beck Anxiety Inventory (r=0.643; P<0.001), vitamin B12 levels (r=0.023; P<0.001), and insulin levels (r=0.257; P<0.05) in obese patients. When receiver operating characteristic curve analysis was used to analyze the suitability of BDNF to identify depression in obese women, the area under the curve for BDNF, 0.756, was found to be significant (P=0.025). BDNF levels lower than 70.2 pg/mL were associated with a higher prevalence of depressive symptoms.ConclusionThe results of our study suggest that the decrease in BDNF levels can be used as a marker for depression diagnosis in obese patients.

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Section: Discussionsupporting

confidence: 88%

Can low brain-derived neurotrophic factor levels be a marker of the presence of depression in obese women?

Güzel¹,

Bakkal²,

Güzel³

et al. 2014

NDT

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“…[102021] In elderly patients with type 2 diabetes, a relatively weak association between NT-proBNP levels and depressive symptoms assessed on the Hospital Anxiety and Depression Scale (HADS) has been observed. [12] In patients with heart failure, individuals underwent depression assessment using the 17-item version Hamilton Depression Scale, and the results revealed that patients with severe depression showed a higher degree of BNP stimulation,[20] which was consistent with the results. Of interest, the plasma concentrations of NT-proBNP were positively correlated with the severity of depression in unmedicated patients with MDD.…”

Section: Discussionmentioning

confidence: 99%

“…[26] Aguiar et al . [20] showed that heart failure patients with severe depression presented higher BNP levels but less cardiac impairment than those without depression or with mild and moderate depression. As mentioned in the introduction, depression is a risk factor for morbidity and mortality in AMI patients; even existing depressive symptoms will have an adverse impact on the cardiovascular prognosis.…”

Section: Discussionmentioning

confidence: 99%

Association between N-terminal proB-type Natriuretic Peptide and Depressive Symptoms in Patients with Acute Myocardial Infarction

Ren

Jia

et al. 2017

Chinese Medical Journal

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Background:While depression and certain cardiac biomarkers are associated with acute myocardial infarction (AMI), the relationship between them remains largely unexplored. We examined the association between depressive symptoms and biomarkers in patients with AMI.Methods:We performed a cross-sectional study using data from 103 patients with AMI between March 2013 and September 2014. The levels of depression, N-terminal proB-type natriuretic peptide (NT-proBNP), and troponin I (TnI) were measured at baseline. The patients were divided into two groups: those with depressive symptoms and those without depressive symptoms according to Zung Self-rating Depression Scale (SDS) score. Baseline comparisons between two groups were made using Student's t-test for continuous variables, Chi-square or Fisher's exact test for categorical variables, and Wilcoxon test for variables in skewed distribution. Binomial logistic regression and multivariate linear regression were performed to assess the association between depressive symptoms and biomarkers while adjusting for demographic and clinical variables.Results:Patients with depressive symptoms had significantly higher NT-proBNP levels as compared to patients without depressive symptoms (1135.0 [131.5, 2474.0] vs. 384.0 [133.0, 990.0], Z = −2.470, P = 0.013). Depressive symptoms were associated with higher NT-proBNP levels (odds ratio [OR] = 2.348, 95% CI: 1.344 to 4.103, P = 0.003) and higher body mass index (OR = 1.169, 95% confidence interval [CI]: 1.016 to 1.345, P = 0.029). The total SDS score was associated with the NT-proBNP level (β = 0.327, 95% CI: 1.674 to 6.119, P = 0.001) after multivariable adjustment. In particular, NT-proBNP was associated with three of the depressive dimensions, including core depression (β = 0.299, 95% CI: 0.551 to 2.428, P = 0.002), cognitive depression (β = 0.320, 95% CI: 0.476 to 1.811, P = 0.001), and somatic depression (β = 0.333, 95% CI: 0.240 to 0.847, P = 0.001). Neither the overall depressive symptomatology nor the individual depressive dimensions were associated with TnI levels.Conclusions:Depressive symptoms, especially core depression, cognitive depression, and somatic depression, were related to high NT-proBNP levels in patients with AMI.

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“…The association of BNP with left ventricular diastolic function appears to be particularly strong in individuals with DM (7). Other studies indicated that BNP was not only associated with left ventricular abnormalities but also with cardiovascular disease and mortality risk in DM patients (8,9). Therefore, when BNP is used to assess cardiovascular disease (CVD) risk in CHF patients, the presence or absence of DM should be taken into account (10,11).…”

Section: Introductionmentioning

confidence: 95%

Levels of B-type natriuretic peptide in chronic heart failure patients with and without diabetes mellitus

Peng

Weitong

et al. 2012

Experimental and Therapeutic Medicine

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The current study aimed to observe the value of B-type natriuretic peptide (BNP) in chronic heart failure (CHF) patients with and without diabetes mellitus (DM). The study consisted of 559 CHF patients, including 276 patients with coronary heart disease, 234 with hypertensive heart disease and 49 with dilated cardiomyopathy. The subjects were divided into non-DM and DM groups which included 384 and 175 patients, respectively. Their New York Heart Association (NYHA) cardiac function degree and BNP levels were detected following admission. Other blood parameters, including fasting blood glucose and serum creatinine, were also collected. Left ventricular ejection fraction (LVEF) and the average thickness of the left ventricular wall (LVW) were detected by echocardiography. The total score of the heart failure (HF)-related parameters was evaluated for each patient according to age, hypertension, LVEF, LVW and NYHA degree. Additionally, BNP-score relation curves were constructed. The levels of BNP were significantly higher in the DM group compared with the non-DM group (1143.73±94.0 vs. 884.34±57.0 ng/l, P<0.05). Positive BNP-score relation curves were obtained for the DM and non-DM groups, but the curve of the DM group was notably steeper. As the patients with DM have significantly higher BNP levels at a similar HF score, DM history and fasting blood glucose should be taken into consideration when evaluating the value of BNP in HF.

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Relação entre depressão, nível de BNP e comprometimento ventricular na insuficiência cardíaca

Abstract: Background: Depression is a common comorbidity in heart failure (HF); however, the mechanisms related to a poorer outcome of depressed patients with HF remain unclear.

Cited by 10 publications

References 23 publications

Can low brain-derived neurotrophic factor levels be a marker of the presence of depression in obese women?

Can low brain-derived neurotrophic factor levels be a marker of the presence of depression in obese women?

Association between N-terminal proB-type Natriuretic Peptide and Depressive Symptoms in Patients with Acute Myocardial Infarction

Levels of B-type natriuretic peptide in chronic heart failure patients with and without diabetes mellitus

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Relação entre depressão, nível de BNP e comprometimento ventricular na insuficiência cardíaca

Abstract: Background: Depression is a common comorbidity in heart failure (HF); however, the mechanisms related to a poorer outcome of depressed patients with HF remain unclear.

Cited by 10 publications

References 23 publications

Can low brain-derived neurotrophic factor levels&nbsp;be a marker of the presence of depression in&nbsp;obese women?

Can low brain-derived neurotrophic factor levels&nbsp;be a marker of the presence of depression in&nbsp;obese women?

Association between N-terminal proB-type Natriuretic Peptide and Depressive Symptoms in Patients with Acute Myocardial Infarction

Levels of B-type natriuretic peptide in chronic heart failure patients with and without diabetes mellitus

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Product

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Can low brain-derived neurotrophic factor levels be a marker of the presence of depression in obese women?

Can low brain-derived neurotrophic factor levels be a marker of the presence of depression in obese women?