Relación del polimorfismo TaqI del gen del receptor de la vitamina D con la lepra lepromatosa en población mexicana

Félix, Jesús Salvador Velarde; Salazar, Silvestre Guadalupe Cázarez; Velázquez, Rafael; Maldonado, José Guadalupe Rendón; Villalobos, Héctor Rangel

doi:10.1590/s0036-36342009000100011

Cited by 16 publications

(11 citation statements)

References 11 publications

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“…To address that question, Pubmed was searched for papers on VDR, osteoporosis and infectious diseases. Papers were found for bones, 53,54 osteoporosis, 55 Mycobacterium malmoense pulmonary disease, 56 tuberculosis, 57,58 acute lower respiratory tract infection, 59 insulin secretory capacity, 60 type 1 diabetes, 61,62 lepromatous leprosy, 63 Staphylococcus aureus infection 64 and advanced prostate cancer. 65,66 For bones, the TT allele frequency was higher for those with higher mean forearm and spine bone mass density.…”

Section: Strength Of Association Data From the National Health Andmentioning

confidence: 99%

Are Hill's criteria for causality satisfied for vitamin D and periodontal disease?

Grant

Boucher

2010

Dermato-Endocrinology

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There is mounting evidence that periodontal disease (PD) is linked to low serum 25-hydroxyvitamin D [25(OH)D] concentrations in addition to recognized risk factors like diet and smoking. This paper reviews this evidence using Hill's criteria for causality in a biological system. Evidence for strength of association, consistency, cohesion and 'dose-effects' [biological 'gradients'] include strong inverse correlations between serum 25(OH) and PD cross-sectionally and that PD is consistently more prevalent in darker vs. lighter skinned people and increases at higher latitudes with analogy for gingivitis and for disorders associated with PD whose risks also increase with hypovitaminosis D. Evidence for plausibility includes that vitamin D increases calcium absorption and protects bone strength; induces formation of cathelicidin and other defensins that combat bacterial infection; reduces tissue production of destructive matrix metalloproteinases actively associated with PD and that prevalence of PD varies with common vitamin D receptor polymorphisms. Experimental evidence from limited supplementation studies [using calcium and vitamin D] shows that supplementation reduces tooth loss. Thus, existing evidence for hypovitaminosis D as a risk factor for PD to date meets Hill's criteria for causality in a biological system. Further experimental evidence for effectiveness and temporality, preferably from randomized controlled trials of vitamin D supplementation [adjusting for other PD risk factors including diet and smoking to reduce confounding] are necessary to confirm causality. If confirmed, dentists and periodontists could perform a valuable service to their patients by discussing the importance of adequate vitamin D status and how to avoid deficiency.

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Section: Strength Of Association Data From the National Health Andmentioning

confidence: 99%

Are Hill's criteria for causality satisfied for vitamin D and periodontal disease?

Grant

Boucher

2010

Dermato-Endocrinology

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“…Futhermore, the expression of the VDR gene among leprosy patients is around 5% to 10% lower when compared with healthy individuals, also reflection in lower levels of 1,25(OH)2D3 in the blood of patients (17). Thus, changes in the 5' region on the VDR gene promoter can alter expression patterns and mRNA levels, while variations on the 3' region (RTU) may affect mRNA stability and efficiency of protein translation (11,15,16). SNP analysis for the FokI rs2228570 region revealed no significant association with leprosy, in line with previous report in India by Sapkota et al (2010).…”

Section: Discussionmentioning

confidence: 99%

Association of the polymorphism of the vitamin D receptor gene (VDR) with the risk of leprosy in the Brazilian Amazon

et al. 2021

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The transmission and evolution of leprosy depends on several aspects, including immunological and genetic factors of the host, as well as genetic factors of Mycobacterium leprae. This study evaluated the association of single nucleotide polymorphisms (SNPs) on the FokI (rs2228570), TaqI (rs731236), ApaI (rs7975232) regions of the vitamin D receptor (VDR) gene with leprosy. A total of 405 individuals were evaluated, composed by groups of 100 multibacillary and 57 paucibacillary patients, and 248 healthy contacts. Blood samples were collected from patients and contacts. The genotyping was performed by sequencing of the interest regions. The alleles of the studied SNPs, and of SNP FokI genotypes, were not associated with leprosy. For the SNP on TaqI region, the relationship between the tt genotype, and for the SNP ApaI, the AA genotype, revealed an association with susceptibility to MB form, while Aa genotype with protection. The extended genotypes AaTT and AaTt of ApaI and TaqI were associated with protection to against MB form. Futher studies analyzing the expression of the VDR gene and the correlation with its SNPs might help to clarify the role of polymorphisms on the immune response in leprosy.

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“…Estudos experimentais com camundongos demonstraram que, diante da deficiência de vitamina D, inflamações foram agravadas (DU et al, 2017). FÉLIX et al, 2009;HADDAD, 2014).…”

Section: Polimorfismos Do Gene Vdr Em Doençasunclassified

Os Efeitos Da Microcorrente E Do Oligoelemento Selênio Nas Disfunções Teciduais Da Face Do Tabagista

Lima¹,

Silva²,

Santos³

et al. 2019

Ciências Biológicas: Campo Promissor Em Pesquisa

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Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição 4.0 Internacional (CC BY 4.0).O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.

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Relación del polimorfismo TaqI del gen del receptor de la vitamina D con la lepra lepromatosa en población mexicana

Abstract: Our data support the association between the TT genotype and susceptibility to LL in this Mexican population.

Cited by 16 publications

References 11 publications

Are Hill's criteria for causality satisfied for vitamin D and periodontal disease?

Are Hill's criteria for causality satisfied for vitamin D and periodontal disease?

Association of the polymorphism of the vitamin D receptor gene (VDR) with the risk of leprosy in the Brazilian Amazon

Os Efeitos Da Microcorrente E Do Oligoelemento Selênio Nas Disfunções Teciduais Da Face Do Tabagista

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