Relación entre modelado miocárdico y función diastólica en pacientes con hipertensión esencial

Cortés, Raquel; Roselló‐Lletí, Esther; Portolés, Manuel; Almenar, Luís; Martínez‐Dolz, Luis; Grigorian, Lilian; Burgos, Fernando Garcı́a de; Carpena, Núria; Salvador, Antonio; Bertoméu, Vicente; Rivera, Miguel

doi:10.1016/j.medcli.2011.08.008

Cited by 2 publications

(2 citation statements)

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“…In the study of Martos et al 24 PIIINP was increased in patients with LVH and HF24. Cortes et al 25 reported that serum PINP and PIIINP were increased in LVH compared to non-hypertrophy ( p = 0.01 and p = 0.005, respectively). Moreover, serum PIIINP was associated with sFas (r = 0.386, p < 0.0001) and sTNFR1 (r = 0.298, p < 0.001)25.…”

Section: Discussionmentioning

confidence: 93%

“…Cortes et al 25 reported that serum PINP and PIIINP were increased in LVH compared to non-hypertrophy ( p = 0.01 and p = 0.005, respectively). Moreover, serum PIIINP was associated with sFas (r = 0.386, p < 0.0001) and sTNFR1 (r = 0.298, p < 0.001)25. Similar results were obtained by Agriniera et al, where the authors showed that PIIINP level was higher in the presence of LVH than without LVH (3.2 ± 1.0 vs. 2.6 ± 0.8 ng/ml, p = 0.001)26.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Biomarkers and Echocardiographic Predictors of Myocardial Dysfunction in Patients with Hypertension

Bielecka‐Dąbrowa

Michalska-Kasiczak

Gluba

et al. 2015

Sci Rep

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The study aimed to identify early echocardiographic and circulating biomarkers of heart failure (HF) in hypertensive patients with normal resting echocardiography. Echocardiography at rest and during exercise, and selected biomarkers were assessed in control group, dyspnea group, and HF group. On exercise dyspnea patients had lower early diastolic (E') and systolic (S') mitral annular velocity (12.8 ± 1.0 vs 14.9 ± 3.0 cm/sec and 9.3 ± 2.0 vs 10.9 ± 2.0 cm/sec, respectively), and higher E/E' ratio compared to control group (6.7 ± 1.0 vs 5.9 ± 1.0) (p < 0.05 for all comparisons). The level of N-terminal propeptide of procollagen type III (PIIINP) was significantly higher in dyspnea group than in controls (p = 0.01). Control and dyspnea patients had lower levels of cardiotrophin-1, cystatin C, syndecan-4, and N terminal–probrain natriuretic peptide than HF patients (all p ≤ 0.01). In multivariate analysis PIIINP (unadjusted odds ratio [OR] = 8.2, 95% confidence interval [Cl] 1.7–40.6; p = 0.001; adjusted OR = 8.7; 95%CI: 1.5–48.3; p = 0.001) and E/E' ratio on exercise (unadjusted OR = 1.8, 95%CI: 0.8–4.0; p = 0.033; adjusted OR = 2.0; 95%CI: 0.8–4.8; p = 0.012) were the only factors significantly associated with the presence of dyspnea. PIIINP is the first early biomarker for the HF development in patients with HA and normal resting echocardiography. Exertional echocardiography may indicate patients with incipient HF with preserved ejection fraction.

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