Relapse of acute myocarditis associated with Campylobacter jejuni enterocolitis

Abstract

Campylobacter infection causes enterocolitis and may also cause various complications such as Guillain-Barré syndrome, reactive arthritis, inflammatory bowel disease, arteritis with aortic dissection, cholecystitis, and acute myocarditis. 1 Acute myocarditis associated with Campylobacter jejuni infection is common in males aged 10-49 years. The affected patients present 3-5 days after the onset of gastroenteritis with chest tightness, chest pain, dyspnea, abnormalities on electrocardiography (ECG), and elevated levels of serum myocardial enzymes. 2 The diagnosis of acute myocarditis associated with C jejuni infection is based on the detection of C jejuni in stool culture or a positive serum antibody titer. 1 Although the prognosis is usually good, there are some reports of mortality or residual mitral valve prolapse. 2,3 There has been no report of relapse of myocarditis associated with C jejuni during follow-up of several weeks. 2,4-6 We herein report the first case of acute relapse of myocarditis associated with C jejuni.

Myocarditis in a Pediatric Patient with Campylobacter Enteritis: A Case Report and Literature Review

“…Chest pain was the main complaint of carditis in the patients described, whereas only one [9] did not have any cardiac symptoms. Laboratory tests demonstrated the release of cardio-specific enzymes (CK, CK-MB, Troponin T/I) in all patients (n = 6) tested for cardiac biomarkers [4][5][6][7][8].…”

“…"myocarditis", "myopericarditis", and "pericarditis" yielded seven relevant cases during the last 20 years in the pediatric population (<18 years old). Specifically, four cases of myopericarditis [4][5][6], two cases of myocarditis [7,8], and one case of pericarditis [9] associated with Campylobacter spp. infection have been described.…”

“…Regarding the characteristics of the patients included in this review, most of them were males (six/seven patients) and the mean age was 16.1 years. Past medical history of the patients was as follows; one patient had β-thalassemia [9], one patient had a previous episode of myopericarditis three years before the current episode [4], one patient suffered from bronchial asthma [8], whereas no comorbidities were reported for the rest of the patients.…”

“…Electrocardiographic and echocardiographic evaluation were performed in six out of seven patients as long as cardiac symptoms were present [4][5][6]8,9]. Abnormal ECG findings were detected in 6 [4][5][6]8,9].…”

“…Electrocardiographic and echocardiographic evaluation were performed in six out of seven patients as long as cardiac symptoms were present [4][5][6]8,9]. Abnormal ECG findings were detected in 6 [4][5][6]8,9]. Specifically, isolated ST-segment elevations [4,5,8,9] or combined with T waves inversions [6] were commonly reported.…”