Relapse of typhoid fever following delayed response to meropenem: A case report and review of previously published cases indicating limited clinical efficacy of meropenem for the treatment of typhoid fever

Blumentrath, Christian Georg; Müller, Gernot; Teichmann, Dieter; Tiesmeier, Jens; Petridou, Jasmina

doi:10.3205/000267

Cited by 4 publications

(1 citation statement)

References 66 publications

(140 reference statements)

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“…Nevertheless, it is a more important to point out that this is a high-cost carbapenemic drug with use restricted to hospitals in Brazil. Moreover, it is a last resort for the treatment of infections and is widely prescribed to human patients with septic conditions in intensive care for severe infections caused by Gram-negative hospital pathogens, including Enterobacteriaceae (Khan et al, 2014;Blumentrath et al, 2019;De Carmargo et al, 2021). Although the recommendations for the use of this drug are restrictive, reservoirs of microorganisms resistant to it are increasing, not only in hospitals, but also in the community and the environment.…”

Section: Wild Birds As Reservoirs Of Multidrug-resistant Enterobacter...mentioning

confidence: 99%

Wild Birds as Reservoirs of Multidrug-Resistant Enterobacteria in Mulungu, Brazil

Beleza,

Maciel,

Carreira

et al. 2024

Braz. J. Poult. Sci.

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Caatinga is a biome unique to Brazil, where degradation caused by anthropogenic actions has led to loss of biodiversity and put many species at risk of extinction. The Ceará state is located within the Caatinga and has a rich avifauna. It comprises 433 species, including 13 species that are in danger of extinction, which are found in the Baturité Massif. The aim of this study was to investigate the frequency and diversity of enterobacteria in wild birds and determine their susceptibility to antimicrobials. Cloacal swab samples were collected from 50 individuals of 28 different species, including the Ceara Gnatheter (Conopophaga cearae) and the Red-necked Tanager (Tangara cyanocephala), which are classified as vulnerable (VU) by the Brazilian Ministry of the Environment. A total of 55 isolates belonging to 14 different species of Enterobacteriaceae were identified. Among them, Pantoea agglomerans and Escherichia coli were the most prevalent species with isolation rates of 36% and 26%, respectively. The highest rate of antimicrobial resistance found was to ampicillin (41.8%), followed by nalidixic acid (36.3%) and amoxicillin associated with clavulanic acid (32.7%). Drugs that presented best efficacy were tobramycin (96.4%), ciprofloxacin (92.6%), and tetracycline (90.9%). Multidrug resistance was observed in 23.5% of the analyzed strains. This research provides important information about the composition of the cloacal microbiota of wild birds in Mulungu, Brazil, as well as their health status. Additionally, these results demonstrate that they harbor multidrug-resistant strains of Enterobacteriaceae.

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Section: Wild Birds As Reservoirs Of Multidrug-resistant Enterobacter...mentioning

confidence: 99%

Wild Birds as Reservoirs of Multidrug-Resistant Enterobacteria in Mulungu, Brazil

Beleza,

Maciel,

Carreira

et al. 2024

Braz. J. Poult. Sci.

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Evaluation of Antimicrobial Susceptibility Profile inSalmonellaTyphi andSalmonellaParatyphi A: Presenting the Current Scenario in India and Strategy for Future Management

Veeraraghavan

Pragasam

Ray

et al. 2021

The Journal of Infectious Diseases

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Background Systematic studies to estimate the disease burden of typhoid and paratyphoid in India are limited. Therefore, a multicenter study on the Surveillance of Enteric Fever in India was carried out to estimate the incidence, clinical presentation, and antimicrobial resistance (AMR) trend. The data presented here represent the national burden of AMR in Salmonella Typhi and Salmonella Paratyphi A. Methods Antimicrobial susceptibility testing was performed for S. Typhi and S. Paratyphi A (n = 2373) isolates collected prospectively during a 2-year period from November 2017 to January 2020. Results Of 2373 Salmonella isolates, 2032 (85.6%) were identified as S. Typhi and 341 (14.4%) were S. Paratyphi A. Approximately 2% of S. Typhi were multidrug-resistant (MDR), whereas all 341 (100%) of S. Paratyphi A isolates were sensitive to the first-line antimicrobials. Among 98% of ciprofloxacin nonsusceptible isolates, resistance (minimum inhibitory concentration [MIC] >0.5 µg/mL) was higher in S. Typhi (37%) compared with S. Paratyphi A (20%). Azithromycin susceptibility was 99.9% and 100% with a mean MIC of 4.98 μg/mL for S. Typhi and 7.39 μg/mL for S. Paratyphi A respectively. Ceftriaxone was the only agent that retained 100% susceptibility. Moreover, beta-lactam/beta-lactamase inhibitors showed potent in vitro activity against the study isolates. Conclusions Data obtained from this systematic surveillance study confirms the declining trend of MDR Salmonella isolates from India. The higher prevalence of ciprofloxacin nonsusceptibility enforces to limit its use and adhere to the judicious usage of azithromycin and ceftriaxone for enteric fever management.

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Wild birds as reservoirs of multidrug-resistant enterobacteria in Mulungu, Brazil

Beleza

Maciel

Carreira

et al. 2021

Preprint

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Caatinga is a biome unique to Brazil that is degraded by anthropogenic actions, which lead to the loss of biodiversity putting many species at risk of extinction. The Ceará State is located in the Caatinga and has a rich avifauna comprised of 433 species including 13 species that are threatened with extinction, which are found in the Baturité Massif. The aim of this study was to investigate the frequency and diversity of enterobacteria in wild birds and to determine their susceptibility to antimicrobials. Cloacal swab samples were collected from 50 individuals of 28 different species, including the Ceara Gnatheter (Conopophaga cearae) and Red-necked Tanager (Tangara cyanocephala cearensis), which are classified as vulnerable (VU) by the Brazilian Ministry of the Environment. A total of 55 isolates belonging to 14 different species of Enterobacteriaceae were identified. Among these, Pantoea agglomerans and Escherichia coli were the most prevalent species with isolation rates of 36% and 26%, respectively. The highest rate of antimicrobial resistance found was to ampicillin (41.8%), followed by nalidixic Acid (36.3%) and amoxicillin associated with clavulanic acid (32.7%). The drugs with the best efficacy were tobramycin (96.4%), ciprofloxacin (92.6%) and tetracycline (90.9%). Multidrug resistance was observed in 23.5% of the analyzed strains. This research provides important information about the composition of the cloacal microbiota of wild birds in Mulungu, Brazil, as well as their health status. In addition, these results demonstrate that they harbor multidrug-resistant strains of Enterobacteriaceae.

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Relapse of typhoid fever following delayed response to meropenem: A case report and review of previously published cases indicating limited clinical efficacy of meropenem for the treatment of typhoid fever

Cited by 4 publications

References 66 publications

Wild Birds as Reservoirs of Multidrug-Resistant Enterobacteria in Mulungu, Brazil

Wild Birds as Reservoirs of Multidrug-Resistant Enterobacteria in Mulungu, Brazil

Evaluation of Antimicrobial Susceptibility Profile inSalmonellaTyphi andSalmonellaParatyphi A: Presenting the Current Scenario in India and Strategy for Future Management

Wild birds as reservoirs of multidrug-resistant enterobacteria in Mulungu, Brazil

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