Relapsing Klebsiella pneumoniae meningitis in a patient with COVID‐19

Abstract

Summary Klebsiella pneumoniae is a common cause of potentially life‐threatening infection. This report describes a relapsing healthcare‐associated Klebsiella pneumoniae meningitis in a 60‐year‐old patient who had SARS‐CoV‐2 infection. During their initial admission for COVID‐19 pneumonitis and treatment with corticosteroids, the patient developed signs and symptoms suggestive of bacterial meningitis. Blood and cerebrospinal fluid cultures confirmed Klebsiella pneumoniae as the causative organism. The patient was treated with a prolonged course of high‐dose meropenem and made an apparent recovery. Four days after hospital discharge, the patient re‐presented critically unwell. Klebsiella pneumoniae was once again isolated from cerebrospinal fluid. During their second admission, the patient deteriorated despite antimicrobial treatment, and life‐sustaining therapies were withdrawn. This case highlights that all COVID‐19 patients receiving immunosuppressive therapy should be monitored for potential opportunistic infection. Prompt recognition and early antimicrobial therapy are key to improving patient outcomes.

Pneumococcal meningitis secondary to otitis media in two patients with COVID-19 omicron variant

“…Prior to the pandemic, we admitted an average of two patients per year to our ICU for bacterial meningitis; by contrast, we did not admit any patients for this condition during the pandemic, which explains why two cases in a single week caught our attention. Although several reports have described otitis media [5,6] and meningitis [7][8][9][10] in patients with COVID-19, to our knowledge, no cases of bacterial meningitis secondary to otitis media in these patients have been described to date. We believe that the development of two such cases in such a short time span is highly unlikely to be coincidental, especially given that involvement of the omicron variant of SARS-CoV-2 is biologically plausible in both of these cases.…”

“…Although several reports have described otitis media [ 5 , 6 ] and meningitis [ 7 – 10 ] in patients with COVID-19, to our knowledge, no cases of bacterial meningitis secondary to otitis media in these patients have been described to date. We believe that the development of two such cases in such a short time span is highly unlikely to be coincidental, especially given that involvement of the omicron variant of SARS-CoV-2 is biologically plausible in both of these cases.…”

Endoscopic lavage of the cerebral ventricular system for ventriculitis treatment in a patient with complicated new coronavirus infection (COVID‑19)

“…В 8 % случаев COVID-19 может сопровождаться развитием бактериальной или грибковой инфекции [2]. В интернетресурсе PubMed (https://pubmed.ncbi.nlm.nih.gov / ) найдено всего несколько описаний развития бактериального менингита у взрослых пациентов с COVID-19 [3][4][5]. Каких-либо обобщающих исследований в этой области не найдено.…”

“…Каких-либо обобщающих исследований в этой области не найдено. Описание хирургического лечения гнойного менингита, осложненного эмпиемой IV желудочка, у пациента с COVID-19 представлено единственным случаем [5].…”